16. Anticoagulation Therapy in Cirrhosis with Portal Vein Thrombosis

  1. Roberto de Franchis MD, AGAF Professor of Gastroenterology Head
  1. Marco Senzolo MD, PhD

Published Online: 17 NOV 2010

DOI: 10.1002/9781444393989.ch16

Portal Hypertension V: Proceedings of the Fifth Baveno International Consensus Workshop, Fifth Edition

Portal Hypertension V: Proceedings of the Fifth Baveno International Consensus Workshop, Fifth Edition

How to Cite

Senzolo, M. (2011) Anticoagulation Therapy in Cirrhosis with Portal Vein Thrombosis, in Portal Hypertension V: Proceedings of the Fifth Baveno International Consensus Workshop, Fifth Edition (ed R. de Franchis), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444393989.ch16

Editor Information

  1. Department of Medical Sciences, University of Milan, and Gastroenterology 3 Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Mangiagalli and Regina Elena Foundation, Milan, Italy

Author Information

  1. Gastroenterology, Department of Surgical and Gastroenterological Sciences, University Hospital of Padua, Padova, Italy

Publication History

  1. Published Online: 17 NOV 2010
  2. Published Print: 14 JAN 2011

ISBN Information

Print ISBN: 9781444334494

Online ISBN: 9781444393989

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Keywords:

  • anticoagulation therapy in cirrhosis - with portal vein thrombosis;
  • patients with chronic or acute liver failure - profound abnormalities in haemostatic system;
  • portal vein thrombosis (PVT) - the most common manifestation;
  • thrombosis risk, substantial - any of the components of Virchow's triad;
  • elevated level of factor VIII - risk factor associated with PVT;
  • patients with cirrhosis and PVT, higher ETP ratio - risk of thrombosis progression into splanchnic vessels;
  • clinical manifestation of PVT - varying from asymptomatic disease to life-threatening complication at first presentation;
  • anticoagulation, to treat portal vein thrombosis in cirrhosis;
  • choice of anticoagulant therapy - and safety of anticoagulation;
  • extensive PVT, precluding transplantation - worsening post-transplantation prognosis

Summary

This chapter contains sections titled:

  • Introduction

  • Pathophysiology

  • Rationale for treatment

  • Anticoagulation to treat portal vein thrombosis in cirrhosis

  • Choice of anticoagulant therapy and safety of anticoagulation

  • Conclusions

  • References