21. Antifibrotic Drugs
- Roberto de Franchis MD, AGAF Professor of Gastroenterology Head
Published Online: 17 NOV 2010
DOI: 10.1002/9781444393989.ch21
Copyright © 2011 Blackwell Publishing Ltd
Book Title
Portal Hypertension V: Proceedings of the Fifth Baveno International Consensus Workshop, Fifth Edition
Additional Information
How to Cite
Pinzani, M. (2011) Antifibrotic Drugs, in Portal Hypertension V: Proceedings of the Fifth Baveno International Consensus Workshop, Fifth Edition (ed R. de Franchis), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444393989.ch21
Editor Information
Department of Medical Sciences, University of Milan, and Gastroenterology 3 Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Mangiagalli and Regina Elena Foundation, Milan, Italy
Publication History
- Published Online: 17 NOV 2010
- Published Print: 14 JAN 2011
ISBN Information
Print ISBN: 9781444334494
Online ISBN: 9781444393989
- Summary
- Chapter
- References
Keywords:
- antifibrotic drugs;
- hepatic fibrogenesis, typical of chronic liver disease (CLD) - reflecting chronic-wound healing reaction, to chronic liver tissue damage;
- hepatic stellate cells (HSC) cultures - isolated from rodent or human liver;
- antifibrogenic agents and their features;
- potential antifibrogenic action of antiviral drugs;
- antiviral treatment (AVT), acting against fibrosis - reduction of liver damage, consequent to viral load reduction;
- angiotensin II receptor blockers;
- antioxidants and “herbal” drugs;
- probiotics, and other strategies - modulating gut flora;
- pathogenic role of conserved pathogen-associated molecular patterns (PAMPs) - and putative contribution to myofibroblast activation
Summary
This chapter contains sections titled:
Introduction
General features of antifibrogenic agents
The potential antifibrogenic action of antiviral drugs
Angiotensin II receptor blockers
Antioxidants and “herbal” drugs
Probiotics and other strategies to modulate the gut flora: is it worth a try?
Antiangiogenic is also antifibrogenic
Compensated cirrhosis: the ideal ground for experimenting antifibrotic drugs
References