5. Clinical Epidemiological and Statistical Challenges in Defining, Recording and Analysing Endpoints

  1. Roberto de Franchis MD, AGAF Professor of Gastroenterology Head
  1. Thorkild Ia Sørensen MD Professor1 and
  2. Per Kragh Andersen PhD, MSC Professor2

Published Online: 17 NOV 2010

DOI: 10.1002/9781444393989.ch5

Portal Hypertension V: Proceedings of the Fifth Baveno International Consensus Workshop, Fifth Edition

Portal Hypertension V: Proceedings of the Fifth Baveno International Consensus Workshop, Fifth Edition

How to Cite

Sørensen, T. I. and Andersen, P. K. (2011) Clinical Epidemiological and Statistical Challenges in Defining, Recording and Analysing Endpoints, in Portal Hypertension V: Proceedings of the Fifth Baveno International Consensus Workshop, Fifth Edition (ed R. de Franchis), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444393989.ch5

Editor Information

  1. Department of Medical Sciences, University of Milan, and Gastroenterology 3 Unit, IRCCS Ca' Granda Ospedale Maggiore Policlinico Mangiagalli and Regina Elena Foundation, Milan, Italy

Author Information

  1. 1

    Institute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark

  2. 2

    Department of Biostatistics, Institute of Public Health, University of Copenhagen, Denmark

Publication History

  1. Published Online: 17 NOV 2010
  2. Published Print: 14 JAN 2011

ISBN Information

Print ISBN: 9781444334494

Online ISBN: 9781444393989

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Keywords:

  • clinical epidemiological and statistical challenges - recording and analysing endpoints;
  • patients with portal hypertension - and clinical course;
  • regression models, influence of covariates - or patient characteristics;
  • prognosis assessment, recording - clinically relevant endpoints;
  • non-differential - versus differential misclassifications;
  • time, fundamental dimension - in clinical epidemiology;
  • timescale choice, and cohort investigation - of who is at risk;
  • surrogate endpoints, a marker of assumed underlying true endpoint;
  • competing endpoints, and special precautions - in data analyses, avoiding bias;
  • changes over time in risk

Summary

This chapter contains sections titled:

  • Introduction

  • Clinical course in patients with portal hypertension

  • Clinical epidemiology deals with these problems

  • Statistical tools

  • Definition and recording of endpoints

  • Definition of observation time

  • Surrogate endpoints

  • Combined endpoints

  • Competing endpoints

  • Changes over time in risk

  • Correlated endpoints

  • Repeated endpoints and multistate models

  • References