1. Normal and Malignant Hematopoiesis

  1. Hussain I. Saba MD, PHD3 and
  2. Ghulam J. Mufti MB, DM, FRCP, FRCPATH4
  1. Bijal D. Shah1 and
  2. Kenneth S. Zuckerman2

Published Online: 24 MAR 2011

DOI: 10.1002/9781444394016.ch1

Advances in Malignant Hematology

Advances in Malignant Hematology

How to Cite

Shah, B. D. and Zuckerman, K. S. (2011) Normal and Malignant Hematopoiesis, in Advances in Malignant Hematology (eds H. I. Saba and G. J. Mufti), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444394016.ch1

Editor Information

  1. 3

    James A. Haley Veterans' Hospital, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, FL, USA

  2. 4

    Department of Haematological Medicine, Guy's and St Thomas' School of Medicine, King's College Hospital, London, UK

Author Information

  1. 1

    University of South Florida, Tampa, Florida, USA

  2. 2

    H. Lee Moffitt Cancer Center, and University of South Florida, Tampa, Florida, USA

Publication History

  1. Published Online: 24 MAR 2011
  2. Published Print: 16 APR 2011

ISBN Information

Print ISBN: 9781405196260

Online ISBN: 9781444394016

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Keywords:

  • hematopoiesis;
  • stem cells;
  • microenvironment;
  • growth factors;
  • cytokines;
  • receptors;
  • transcription factors;
  • microRNA;
  • signal transduction;
  • leukemia stem cells

Summary

Hematopoiesis is the process by which immature pluripotent hematopoietic stem cells (HSC) self-renew or differentiate into any of the mature blood cell lineages. The repopulating HSC are rare, but through their capacity to both self-renew and differentiate, they maintain the ability of the bone marrow to produce more than a quadrillion blood cells throughout a normal lifespan. Self-renewal, proliferation, and differentiation are influenced by delicate balances of complex regulatory processes, including cellular and extracellular matrix components of the hematopoietic microenvironment, growth factors, signal transduction pathways, transcription factors, and microRNAs. Normal hematopoietic progenitors can be transformed into leukemia cells by dysregulation of these processes, caused by mutations in genes encoding critical regulatory molecules. A small population of leukemia stem cells is primarily responsible for maintaining leukemia cell survival and proliferation. Understanding the principal mechanisms governing hematopoiesis is critical to deconstructing the pathways that drive hematologic malignancy and identifying potential therapeutic targets.