23. Advances in Allogeneic Hematopoietic Cell Transplantation: Progress in Transplantation Technology and Disease-Specific Outcomes

  1. Hussain I. Saba MD, PHD2 and
  2. Ghulam J. Mufti MB, DM, FRCP, FRCPATH3
  1. Joseph Pidala and
  2. Claudio Anasetti

Published Online: 24 MAR 2011

DOI: 10.1002/9781444394016.ch23

Advances in Malignant Hematology

Advances in Malignant Hematology

How to Cite

Pidala, J. and Anasetti, C. (2011) Advances in Allogeneic Hematopoietic Cell Transplantation: Progress in Transplantation Technology and Disease-Specific Outcomes, in Advances in Malignant Hematology (eds H. I. Saba and G. J. Mufti), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444394016.ch23

Editor Information

  1. 2

    James A. Haley Veterans' Hospital, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, FL, USA

  2. 3

    Department of Haematological Medicine, Guy's and St Thomas' School of Medicine, King's College Hospital, London, UK

Author Information

  1. Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center, and University of South Florida, Tampa, Florida, USA

Publication History

  1. Published Online: 24 MAR 2011
  2. Published Print: 16 APR 2011

ISBN Information

Print ISBN: 9781405196260

Online ISBN: 9781444394016

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Keywords:

  • allogeneic hematopoietic cell transplantation;
  • graft-versus-host disease;
  • hematopoietic stem cell source;
  • acute myelogenous leukemia;
  • myelodysplastic syndrome;
  • chronic myelogenous leukemia;
  • acute lymphoblastic leukemia;
  • chronic lymphocytic leukemia;
  • non-Hodgkin lymphoma;
  • multiple myeloma

Summary

While allogeneic hematopoietic cell transplantation (HCT) provides effective control and often cure of hematopoietic malignancies, donor availability and limitations in resolution of HLA typing, transplant regimen-related toxicity, morbidity and mortality from graft-versus-host disease, infectious complications, and relapse of the original disease have circumscribed its overall success. While several challenges remain, major advances in transplantation technology, as well as novel approaches in disease-specific investigation have improved outcomes, thereby increasing the overall benefit realized with this therapy. The aim of this chapter is to examine major developments in transplantation technology, and to review results of current transplantation approaches in disease-specific outcomes.