6. The Molecular Biology of Acute Myeloid Leukemia

  1. Hussain I. Saba MD, PHD2 and
  2. Ghulam J. Mufti MB, DM, FRCP, FRCPATH3
  1. Jerald Radich

Published Online: 24 MAR 2011

DOI: 10.1002/9781444394016.ch6

Advances in Malignant Hematology

Advances in Malignant Hematology

How to Cite

Radich, J. (2011) The Molecular Biology of Acute Myeloid Leukemia, in Advances in Malignant Hematology (eds H. I. Saba and G. J. Mufti), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444394016.ch6

Editor Information

  1. 2

    James A. Haley Veterans' Hospital, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, FL, USA

  2. 3

    Department of Haematological Medicine, Guy's and St Thomas' School of Medicine, King's College Hospital, London, UK

Author Information

  1. Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Publication History

  1. Published Online: 24 MAR 2011
  2. Published Print: 16 APR 2011

ISBN Information

Print ISBN: 9781405196260

Online ISBN: 9781444394016



  • AML;
  • cytogenetics;
  • signal transduction;
  • RAS;
  • FLT3;
  • NPM1;
  • gene expression profiling


Acute myeloid leukemia (AML) is a heterogeneous disease driven by a wide variety of genetic lesions. The study of the molecular biology of AML has not only given us an understanding of the process of leukemogenesis, but has allowed us to adopt risk stratification strategies based on a patient's pattern of cytogenetic and mutational status. Further, the discovery of specific genes mutated in AML provides new targets for both drug development and diagnostic methods aimed at the detection of minimal residual disease. Ongoing work using gene expression and methylation profiling promises to uncover more pathways relevant for leukemia diagnosis and treatment.