13. Neuropsychologic Features of Parkinson's Dementias

  1. C. Warren Olanow MD, FRCPC2,3,4,
  2. Fabrizio Stocchi MD, PhD5 and
  3. Anthony E. Lang MD, FRCPC6,7,8
  1. Leonardo Cruz de Souza MD,
  2. Virginie Czernecki PhD and
  3. Bruno Dubois MD

Published Online: 27 JUN 2011

DOI: 10.1002/9781444397970.ch13

Parkinson's Disease: Non-Motor and Non-Dopaminergic Features

Parkinson's Disease: Non-Motor and Non-Dopaminergic Features

How to Cite

de Souza, L. C., Czernecki, V. and Dubois, B. (2011) Neuropsychologic Features of Parkinson's Dementias, in Parkinson's Disease: Non-Motor and Non-Dopaminergic Features (eds C. W. Olanow, F. Stocchi and A. E. Lang), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444397970.ch13

Editor Information

  1. 2

    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA

  2. 3

    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA

  3. 4

    Robert and John M. Bendheim Parkinson's Disease Center, Mount Sinai School of Medicine, New York, NY, USA

  4. 5

    Parkinson's Disease and Movement Disorders Research Centre, Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy

  5. 6

    Division of Neurology, University of Toronto, Toronto, ON, Canada

  6. 7

    Parkinson's Disease Research, University of Toronto, Toronto, ON, Canada

  7. 8

    Movement Disorder Centre, Toronto Western Hospital, Toronto, ON, Canada

Author Information

  1. Department of Neurology, Salpêtrière University Hospital, Paris, France

Publication History

  1. Published Online: 27 JUN 2011
  2. Published Print: 29 JUL 2011

ISBN Information

Print ISBN: 9781405191852

Online ISBN: 9781444397970

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Keywords:

  • Parkinson's disease dementia;
  • diagnostic criteria;
  • Lewy body dementia;
  • pill questionnaire

Summary

The awareness that dementia occurs with high frequency during the course of Parkinson's disease, and the reported efficacy of cholinergic enhancers for this indication, have increased interest in Parkinson's disease dementia and its associated cognitive features. A precise diagnosis may be difficult to make; however, given (i) the cognitive slowing and executive dysfunction that are generally part of the clinical features of PD, (ii) the absence of clear cut separation between mild cognitive impairment and dementia in PD, and (iii) the presence of possible confounding factors that may interfere with the evaluation of cognitive functions (e.g., slurred speech, depressive mood, cognitive side effects of dopaminergic drugs or anticholinergic therapy), the recent proposal putting forth criteria for the diagnosis of PD dementia may be useful for making a more definitive diagnosis that is relevant for clinical research, clinical trials, and pharmacotherapy.