17. Depression in Parkinson's Disease

  1. C. Warren Olanow MD, FRCPC2,3,4,
  2. Fabrizio Stocchi MD, PhD5 and
  3. Anthony E. Lang MD, FRCPC6,7,8
  1. Tiffini Voss MD and
  2. Irene Hegeman Richard MD

Published Online: 27 JUN 2011

DOI: 10.1002/9781444397970.ch17

Parkinson's Disease: Non-Motor and Non-Dopaminergic Features

Parkinson's Disease: Non-Motor and Non-Dopaminergic Features

How to Cite

Voss, T. and Hegeman Richard, I. (2011) Depression in Parkinson's Disease, in Parkinson's Disease: Non-Motor and Non-Dopaminergic Features (eds C. W. Olanow, F. Stocchi and A. E. Lang), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444397970.ch17

Editor Information

  1. 2

    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA

  2. 3

    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA

  3. 4

    Robert and John M. Bendheim Parkinson's Disease Center, Mount Sinai School of Medicine, New York, NY, USA

  4. 5

    Parkinson's Disease and Movement Disorders Research Centre, Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy

  5. 6

    Division of Neurology, University of Toronto, Toronto, ON, Canada

  6. 7

    Parkinson's Disease Research, University of Toronto, Toronto, ON, Canada

  7. 8

    Movement Disorder Centre, Toronto Western Hospital, Toronto, ON, Canada

Author Information

  1. Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA

Publication History

  1. Published Online: 27 JUN 2011
  2. Published Print: 29 JUL 2011

ISBN Information

Print ISBN: 9781405191852

Online ISBN: 9781444397970

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Keywords:

  • deep brain stimulation;
  • depression;
  • disability;
  • quality-of-life;
  • Parkinson's disease;
  • rating scales;
  • serotonin–norepinephrine reuptake inhibitor (SNRI);
  • selective serotonin reuptake inhibitor (SSRI);
  • tricyclic anti-depressant (TCA)

Summary

Depressive symptoms are common in Parkinson disease (PD) and negatively impact function and quality-of-life. Unfortunately, depression remains under-recognized and undertreated in this population. While the specific pathophysiology of PD depression (dPD) is not fully understood, this chapter reviews the current understanding of its etiology and phenomenology. In addition, issues of particular relevance to the diagnosis and treatment of depression in the setting of PD are addressed.