23. REM Sleep Behavior Disorder and Neurodegenerative Disorders

  1. C. Warren Olanow MD, FRCPC2,3,4,
  2. Fabrizio Stocchi MD, PhD5 and
  3. Anthony E. Lang MD, FRCPC6,7,8
  1. Mark W. Mahowald MD,
  2. Carlos H. Schenck MD and
  3. Michel A. Cramer Bornemann MD

Published Online: 27 JUN 2011

DOI: 10.1002/9781444397970.ch23

Parkinson's Disease: Non-Motor and Non-Dopaminergic Features

Parkinson's Disease: Non-Motor and Non-Dopaminergic Features

How to Cite

Mahowald, M. W., Schenck, C. H. and Cramer Bornemann, M. A. (2011) REM Sleep Behavior Disorder and Neurodegenerative Disorders, in Parkinson's Disease: Non-Motor and Non-Dopaminergic Features (eds C. W. Olanow, F. Stocchi and A. E. Lang), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444397970.ch23

Editor Information

  1. 2

    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA

  2. 3

    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA

  3. 4

    Robert and John M. Bendheim Parkinson's Disease Center, Mount Sinai School of Medicine, New York, NY, USA

  4. 5

    Parkinson's Disease and Movement Disorders Research Centre, Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy

  5. 6

    Division of Neurology, University of Toronto, Toronto, ON, Canada

  6. 7

    Parkinson's Disease Research, University of Toronto, Toronto, ON, Canada

  7. 8

    Movement Disorder Centre, Toronto Western Hospital, Toronto, ON, Canada

Author Information

  1. Minnesota Regional Sleep Disorders Center and Hennepin County Medical Center, University of Minnesota Medical School, Minneapolis, MN, USA

Publication History

  1. Published Online: 27 JUN 2011
  2. Published Print: 29 JUL 2011

ISBN Information

Print ISBN: 9781405191852

Online ISBN: 9781444397970

SEARCH

Keywords:

  • sleep;
  • rapid eye movement (REM) sleep behavior disorder (RBD);
  • oneiric behavior;
  • dream-enacting behavior;
  • Parkinson's disease;
  • polysomnography

Summary

Rapid eye movement (REM) sleep behavior disorder (RBD) is a fascinating experiment in Nature predicted decades ago by animal studies. RBD is characterized by the absence of muscle atonia during REM sleep, resulting in the appearance of dream enactment, which may result in violent or injurious behaviors. RBD typically affects men over the age of 50, and responds exquisitely to clonazepam. Over time, the majority of individuals with RBD will eventually develop additional signs and symptoms of a number of neurodegenerative disorders, notably one of the synucleinopathies (Parkinson disease, dementia with Lewy body disease, or multiple system atrophy), often after a prolonged interval lasting more than 10 years. RBD is commonly induced by medications, most notably tricyclic anti-depressants and serotonin-specific reuptake inhibitors.