3. Non-Dopaminergic Pathology of Parkinson's Disease

  1. C. Warren Olanow MD, FRCPC2,3,4,
  2. Fabrizio Stocchi MD, PhD5 and
  3. Anthony E. Lang MD, FRCPC6,7,8
  1. Heiko Braak MD and
  2. Kelly Del Tredici MD, PhD

Published Online: 27 JUN 2011

DOI: 10.1002/9781444397970.ch3

Parkinson's Disease: Non-Motor and Non-Dopaminergic Features

Parkinson's Disease: Non-Motor and Non-Dopaminergic Features

How to Cite

Braak, H. and Del Tredici, K. (2011) Non-Dopaminergic Pathology of Parkinson's Disease, in Parkinson's Disease: Non-Motor and Non-Dopaminergic Features (eds C. W. Olanow, F. Stocchi and A. E. Lang), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444397970.ch3

Editor Information

  1. 2

    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA

  2. 3

    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA

  3. 4

    Robert and John M. Bendheim Parkinson's Disease Center, Mount Sinai School of Medicine, New York, NY, USA

  4. 5

    Parkinson's Disease and Movement Disorders Research Centre, Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy

  5. 6

    Division of Neurology, University of Toronto, Toronto, ON, Canada

  6. 7

    Parkinson's Disease Research, University of Toronto, Toronto, ON, Canada

  7. 8

    Movement Disorder Centre, Toronto Western Hospital, Toronto, ON, Canada

Author Information

  1. Clinical Neuroanatomy, Department of Neurology, Center for Clinical Research, University of Ulm, Ulm, Germany

Publication History

  1. Published Online: 27 JUN 2011
  2. Published Print: 29 JUL 2011

ISBN Information

Print ISBN: 9781405191852

Online ISBN: 9781444397970

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Keywords:

  • α-synuclein/synucleinopathy;
  • autonomic nervous system;
  • enteric nervous system;
  • neuroanatomy;
  • Lewy body disease;
  • Lewy neurites/bodies;
  • neuropathology;
  • sporadic Parkinson's disease;
  • peripheral nervous system;
  • preclinical Parkinson's disease;
  • spinal cord;
  • submandibular gland

Summary

The pathologic process associated with the synucleinopathy sporadic Parkinson's disease (sPD) is not confined to the brain or to the dopaminergic system. In preclinical (incidental Lewy body disease) and clinical PD cases, the same types of inclusions (Lewy pathology) are seen at autopsy within the same selectively vulnerable types of cells at specific sites throughout the brain and in other parts of the human nervous system, including the spinal cord and peripheral as well as enteric nervous systems. The procedure for staging Lewy pathology summarized in this chapter not only indicates that sPD is progressive but, at the same time, provides a framework with which we can study the topographical distribution pattern and, presumably, disease progression at other nervous system locations in relation to the pathological process associated with sPD in the brain.