7. Animal Models of Parkinson's Disease: The Non-Motor and Non-Dopaminergic Features

  1. C. Warren Olanow MD, FRCPC2,3,4,
  2. Fabrizio Stocchi MD, PhD5 and
  3. Anthony E. Lang MD, FRCPC6,7,8
  1. Katherine E. Soderstrom BA1,
  2. Shilpa Ramaswamy PhD1,
  3. C. Warren Olanow MD, FRCPC2,3,4 and
  4. Jeffrey H. Kordower PhD1

Published Online: 27 JUN 2011

DOI: 10.1002/9781444397970.ch7

Parkinson's Disease: Non-Motor and Non-Dopaminergic Features

Parkinson's Disease: Non-Motor and Non-Dopaminergic Features

How to Cite

Soderstrom, K. E., Ramaswamy, S., Olanow, C. W. and Kordower, J. H. (2011) Animal Models of Parkinson's Disease: The Non-Motor and Non-Dopaminergic Features, in Parkinson's Disease: Non-Motor and Non-Dopaminergic Features (eds C. W. Olanow, F. Stocchi and A. E. Lang), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444397970.ch7

Editor Information

  1. 2

    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA

  2. 3

    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA

  3. 4

    Robert and John M. Bendheim Parkinson's Disease Center, Mount Sinai School of Medicine, New York, NY, USA

  4. 5

    Parkinson's Disease and Movement Disorders Research Centre, Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy

  5. 6

    Division of Neurology, University of Toronto, Toronto, ON, Canada

  6. 7

    Parkinson's Disease Research, University of Toronto, Toronto, ON, Canada

  7. 8

    Movement Disorder Centre, Toronto Western Hospital, Toronto, ON, Canada

Author Information

  1. 1

    Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA

  2. 2

    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA

  3. 3

    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA

  4. 4

    Robert and John M. Bendheim Parkinson's Disease Center, Mount Sinai School of Medicine, New York, NY, USA

Publication History

  1. Published Online: 27 JUN 2011
  2. Published Print: 29 JUL 2011

ISBN Information

Print ISBN: 9781405191852

Online ISBN: 9781444397970

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Keywords:

  • animal models of Parkinson's disease - non-motor and non-dopaminergic features;
  • Parkinson's disease (PD) - resting tremor, rigidity, bradykinesia and gait disturbance;
  • PD pathology, well beyond nigrostriatal dopamine system;
  • Braak and colleagues's pattern of α-synuclein pathology - in aging control;
  • classic models of PD - 6-Hydroxydopamine (6-OHDA), dopamine analog via dopamine transporter;
  • novel models of PD - genetic models of PD;
  • animal models, assessing non-motor - and non-dopaminergic features of PD;
  • sleep disturbance, as symptom of PD - problematic for PD patients;
  • neuropsychiatric dysfunction - depression, comorbidities associated with PD;
  • visual hallucinations, debilitating side effects - of dopamine replacement

Summary

This chapter contains sections titled:

  • Parkinson's disease

  • Classic PD models

  • Use of animal models to assess the non-motor and non-dopaminergic features of PD

  • Therapy-induced non-motor features of PD

  • Conclusion

  • References