8. The Emerging Entity of Pre-Motor Parkinson's Disease

  1. C. Warren Olanow MD, FRCPC2,3,4,
  2. Fabrizio Stocchi MD, PhD5 and
  3. Anthony E. Lang MD, FRCPC6,7,8
  1. J. William Langston MD

Published Online: 5 OCT 2011

DOI: 10.1002/9781444397970.ch8

Parkinson's Disease: Non-Motor and Non-Dopaminergic Features

Parkinson's Disease: Non-Motor and Non-Dopaminergic Features

How to Cite

Langston, J. W. (2011) The Emerging Entity of Pre-Motor Parkinson's Disease, in Parkinson's Disease: Non-Motor and Non-Dopaminergic Features (eds C. W. Olanow, F. Stocchi and A. E. Lang), Blackwell Publishing Ltd., Oxford, UK. doi: 10.1002/9781444397970.ch8

Editor Information

  1. 2

    Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA

  2. 3

    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA

  3. 4

    Robert and John M. Bendheim Parkinson's Disease Center, Mount Sinai School of Medicine, New York, NY, USA

  4. 5

    Parkinson's Disease and Movement Disorders Research Centre, Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy

  5. 6

    Division of Neurology, University of Toronto, Toronto, ON, Canada

  6. 7

    Parkinson's Disease Research, University of Toronto, Toronto, ON, Canada

  7. 8

    Movement Disorder Centre, Toronto Western Hospital, Toronto, ON, Canada

Author Information

  1. Parkinson's Institute, Sunnyvale, CA, USA

Publication History

  1. Published Online: 5 OCT 2011
  2. Published Print: 29 JUL 2011

ISBN Information

Print ISBN: 9781405191852

Online ISBN: 9781444397970

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Keywords:

  • Parkinson's disease;
  • pre-motor;
  • Lewy body;
  • synucleinopathy;
  • REM sleep disorder;
  • depression;
  • dementia;
  • olfaction;
  • hyposmia;
  • pure autonomic failure;
  • cardiac sympathetic denervation;
  • α-synuclein;
  • constipation;
  • Lewy body disease

Summary

This chapter provides a comprehensive review of the rapidly increasing array of clinical signs and symptoms that can now justifiably be called pre-motor Parkinson's disease (PD). Many of these overlap with other clinical entities. However, it is now becoming clear that these pre-motor features of PD have the potential to enhance our understanding of disease evolution and provide a window into early disease diagnosis. It is also becoming apparent that these pre-motor features will help unify the array of Lewy body disorders that have been defined to date. Indeed, several of these pre-motor features may provide a central core to all Lewy body diseases, which in turn could help shape a comprehensive approach to their diagnosis and treatment. It is concluded that a prospective, population-based study is now warranted to define fully the entity of pre-motor PD.