1. Aging of the Human Neuromuscular System: Pathological Aspects

  1. Valerie Askanas MD, PhD and
  2. W. King Engel MD
  1. W. King Engel MD and
  2. Valerie Askanas MD, PhD

Published Online: 19 DEC 2011

DOI: 10.1002/9781444398311.ch1

Muscle Aging, Inclusion-Body Myositis and Myopathies

Muscle Aging, Inclusion-Body Myositis and Myopathies

How to Cite

Engel, W. K. and Askanas, V. (2012) Aging of the Human Neuromuscular System: Pathological Aspects, in Muscle Aging, Inclusion-Body Myositis and Myopathies (eds V. Askanas and W. K. Engel), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444398311.ch1

Editor Information

  1. Departments of Neurology and Pathology, University of Southern California Neuromuscular Center, University of Southern California Keck School of Medicine, Good Samaritan Hospital, Los Angeles, CA, USA

Author Information

  1. Departments of Neurology and Pathology, University of Southern California Neuromuscular Center, University of Southern California Keck School of Medicine, Good Samaritan Hospital, Los Angeles, CA, USA

Publication History

  1. Published Online: 19 DEC 2011
  2. Published Print: 27 JAN 2012

ISBN Information

Print ISBN: 9781405196468

Online ISBN: 9781444398311

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Keywords:

  • aging muscle;
  • cachectic muscle atrophy;
  • denervation muscle atrophy;
  • neuropathy in aging;
  • type-2 muscle-fiber atrophy

Summary

This chapter presents the most typical histological and pathologic features of aging human muscle associated with progressive muscle weakness that occurs in a clinical setting. Also discussed is a scientific analysis of the known and putative pathogenic mechanisms, and potential avenues for treatment.