10. Pathologic Diagnostic Criteria of Sporadic Inclusion-Bodyc Myositis and Hereditary Inclusion-Body Myopathy Muscle Biopsies

  1. Valerie Askanas MD, PhD and
  2. W. King Engel MD
  1. Valerie Askanas MD, PhD and
  2. W. King Engel MD

Published Online: 19 DEC 2011

DOI: 10.1002/9781444398311.ch10

Muscle Aging, Inclusion-Body Myositis and Myopathies

Muscle Aging, Inclusion-Body Myositis and Myopathies

How to Cite

Askanas, V. and Engel, W. K. (2012) Pathologic Diagnostic Criteria of Sporadic Inclusion-Bodyc Myositis and Hereditary Inclusion-Body Myopathy Muscle Biopsies, in Muscle Aging, Inclusion-Body Myositis and Myopathies (eds V. Askanas and W. K. Engel), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444398311.ch10

Editor Information

  1. Departments of Neurology and Pathology, University of Southern California Neuromuscular Center, University of Southern California Keck School of Medicine, Good Samaritan Hospital, Los Angeles, CA, USA

Author Information

  1. Departments of Neurology and Pathology, University of Southern California Neuromuscular Center, University of Southern California Keck School of Medicine, Good Samaritan Hospital, Los Angeles, CA, USA

Publication History

  1. Published Online: 19 DEC 2011
  2. Published Print: 27 JAN 2012

ISBN Information

Print ISBN: 9781405196468

Online ISBN: 9781444398311

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Keywords:

  • Congo red;
  • crystal violet;
  • Engel trichrome staining;
  • hereditary inclusion-body myopathy due to GNE mutation;
  • hereditary inclusion-body myopathy due to VCP mutation;
  • sporadic inclusion-body myositis;
  • p62;
  • TAR DNA-binding protein 43;
  • TDP-43;
  • vacuolated muscle fibers

Summary

This chapter discusses muscle biopsy pathologic criteria that we recommend for diagnosing sporadic inclusion-body myositis (s-IBM) and hereditary inclusion-body myopathies (h-IBMs). We emphasize that proper evaluation of a muscle biopsy is the only reliable method to diagnose s-IBM and h-IBMs. Described and illustrated are various light-microscopic stainings and immunostainings that we consider necessary for the correct pathologic diagnosis. The findings that are present but which are neither characteristic nor diagnostic are also described.