22. Bone Marrow Processing and Normal Morphology

  1. Kandice Kottke-Marchant MD, PhD2,3,4 and
  2. Bruce H. Davis MD5
  1. Karl S. Theil MD

Published Online: 8 AUG 2012

DOI: 10.1002/9781444398595.ch22

Laboratory Hematology Practice

Laboratory Hematology Practice

How to Cite

Theil, K. S. (2012) Bone Marrow Processing and Normal Morphology, in Laboratory Hematology Practice (eds K. Kottke-Marchant and B. H. Davis), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444398595.ch22

Editor Information

  1. 2

    Pathology & Laboratory Medicine Institute, Cleveland, OH, USA

  2. 3

    Department of Pathology, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA

  3. 4

    Hemostasis and Thrombosis, Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH, USA

  4. 5

    Trillium Diagnostics, LLC, Bangor, ME, USA

Author Information

  1. Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH, USA

Publication History

  1. Published Online: 8 AUG 2012
  2. Published Print: 10 APR 2012

ISBN Information

Print ISBN: 9781405162180

Online ISBN: 9781444398595



  • bone marrow aspirate;
  • bone marrow biopsy;
  • bone marrow histology;
  • reticulin stain


Histopathologic examination of the bone marrow is a critical part of the evaluation of patients with hematologic and nonhematologic disorders. A comprehensive evaluation requires the integration of morphologic findings in the aspirate smear and core biopsy with special stains and ancillary studies. The methods for procuring, processing, and analyzing bone marrow aspirate and biopsy specimens are discussed, along with routine stains and some more commonly performed special stains. The features of normal hematopoiesis as seen in bone marrow aspirate smears and biopsy sections are reviewed, along with guidelines for interpretive reporting.