25. Myelodysplastic Disorders

  1. Kandice Kottke-Marchant MD, PhD4,5,6 and
  2. Bruce H. Davis MD7
  1. Maryalice Stetler-Stevenson MD, PhD1,
  2. Joseph A. DiGiuseppe MD, PhD2 and
  3. Diane C. Arthur MD3

Published Online: 8 AUG 2012

DOI: 10.1002/9781444398595.ch25

Laboratory Hematology Practice

Laboratory Hematology Practice

How to Cite

Stetler-Stevenson, M., DiGiuseppe, J. A. and Arthur, D. C. (2012) Myelodysplastic Disorders, in Laboratory Hematology Practice (eds K. Kottke-Marchant and B. H. Davis), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444398595.ch25

Editor Information

  1. 4

    Pathology & Laboratory Medicine Institute, Cleveland, OH, USA

  2. 5

    Department of Pathology, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA

  3. 6

    Hemostasis and Thrombosis, Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH, USA

  4. 7

    Trillium Diagnostics, LLC, Bangor, ME, USA

Author Information

  1. 1

    Flow Cytometry Unit, Laboratory of Pathology, CCR, NCI, NIH, Bethesda, MD, USA

  2. 2

    Department of Pathology & Laboratory Medicine, Hartford Hospital, Hartford, CT, USA

  3. 3

    Clinical Cytogenetics Section, Laboratory of Pathology, CCR, NCI, NIH, Bethesda, MD, USA

Publication History

  1. Published Online: 8 AUG 2012
  2. Published Print: 10 APR 2012

ISBN Information

Print ISBN: 9781405162180

Online ISBN: 9781444398595

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Keywords:

  • myelodysplastic syndromes;
  • dyserythropoiesis;
  • dysgranulopoiesis;
  • dysmegakaryopoiesis;
  • cytogenetics;
  • flow cytometry

Summary

The myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell diseases that are prevalent hematologic malignancies and increasing in frequency. Their diagnosis is based upon clinical history, peripheral blood morphology, bone marrow morphology, flow cytometry, and cytogenetics. The criteria for diagnosis and subclassification, as well as characteristic morphology, flow cytometry, and cytogenetic findings are discussed. Factors that impact prognosis are summarized. An example case that demonstrates the correlation of morphology, cytogenetics, and flow cytometry in the diagnostic evaluation is presented.