27. Lymphoproliferative Disorders

  1. Kandice Kottke-Marchant MD, PhD3,4,5 and
  2. Bruce H. Davis MD6
  1. Robert W. Allan MD1,
  2. Samer Z. Al-Quran MD2,
  3. Ying Li MD, PhD1 and
  4. Raul C. Braylan MD1

Published Online: 8 AUG 2012

DOI: 10.1002/9781444398595.ch27

Laboratory Hematology Practice

Laboratory Hematology Practice

How to Cite

Allan, R. W., Al-Quran, S. Z., Li, Y. and Braylan, R. C. (2012) Lymphoproliferative Disorders, in Laboratory Hematology Practice (eds K. Kottke-Marchant and B. H. Davis), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444398595.ch27

Editor Information

  1. 3

    Pathology & Laboratory Medicine Institute, Cleveland, OH, USA

  2. 4

    Department of Pathology, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA

  3. 5

    Hemostasis and Thrombosis, Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH, USA

  4. 6

    Trillium Diagnostics, LLC, Bangor, ME, USA

Author Information

  1. 1

    Department of Pathology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA

  2. 2

    Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA

Publication History

  1. Published Online: 8 AUG 2012
  2. Published Print: 10 APR 2012

ISBN Information

Print ISBN: 9781405162180

Online ISBN: 9781444398595



  • lymphoproliferative disorders;
  • lymphomas;
  • leukemias;
  • diagnosis


Lymphoproliferative disorders, as defined in this chapter, comprise a heterogeneous group of disorders characterized by an uncontrolled proliferation and/or accumulation of genetically altered lymphocytes. Because the origin, developmental stage, and genetic makeup of the involved lymphocytes vary widely, the clinical manifestations of lymphoproliferative disorders are extremely diverse. In this chapter, the general clinical and laboratory manifestations of these disorders are reviewed, along with the common laboratory approaches that are used in their recognition and classification. Further details of individual diseases, including their significant morphologic and biologic features and a succinct description of their usual clinical expression, are presented, with an emphasis on those disorders that often affect bone marrow and peripheral blood.