31. Sample Collection and Processing in Hemostasis

  1. Kandice Kottke-Marchant MD, PhD2,3,4 and
  2. Bruce H. Davis MD5
  1. Dorothy M. Adcock MD

Published Online: 8 AUG 2012

DOI: 10.1002/9781444398595.ch31

Laboratory Hematology Practice

Laboratory Hematology Practice

How to Cite

Adcock, D. M. (2012) Sample Collection and Processing in Hemostasis, in Laboratory Hematology Practice (eds K. Kottke-Marchant and B. H. Davis), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781444398595.ch31

Editor Information

  1. 2

    Pathology & Laboratory Medicine Institute, Cleveland, OH, USA

  2. 3

    Department of Pathology, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA

  3. 4

    Hemostasis and Thrombosis, Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH, USA

  4. 5

    Trillium Diagnostics, LLC, Bangor, ME, USA

Author Information

  1. Esoterix Inc., Englewood, CO, USA

Publication History

  1. Published Online: 8 AUG 2012
  2. Published Print: 10 APR 2012

ISBN Information

Print ISBN: 9781405162180

Online ISBN: 9781444398595



  • pre-analytical, hemostasis testing;
  • coagulation;
  • sodium citrate;
  • APTT;
  • PT;
  • specimen collection;
  • specimen storage


The pre-analytical phase of hemostasis testing is the phase of testing that is most prone to errors that may impact laboratory assay results. The effect on results can be clinically significant and can therefore impact patient management leading to mistaken diagnosis and treatment. Knowledge of and adherence to guidelines on proper sample collection and processing is therefore paramount to providing accurate and reliable hemostasis laboratory results. This chapter reviews the variables associated with specimen collection, transportation, processing, and storage, the guidelines that should be followed, and provides information as to the potential impact of these variables.