Chapter 10. Zebrafish as a Model System for Successful Spinal Cord Regeneration

  1. Dr. Catherina G. Becker and
  2. Dr. Thomas Becker
  1. Catherina G. Becker and
  2. Thomas Becker

Published Online: 5 FEB 2007

DOI: 10.1002/9783527610365.ch10

Model Organisms in Spinal Cord Regeneration

Model Organisms in Spinal Cord Regeneration

How to Cite

Becker, C. G. and Becker, T. (2006) Zebrafish as a Model System for Successful Spinal Cord Regeneration, in Model Organisms in Spinal Cord Regeneration (eds C. G. Becker and T. Becker), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527610365.ch10

Editor Information

  1. Centre for Neuroscience Research, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK

Author Information

  1. Centre for Neuroscience Research, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK

Publication History

  1. Published Online: 5 FEB 2007
  2. Published Print: 15 DEC 2006

ISBN Information

Print ISBN: 9783527315048

Online ISBN: 9783527610365

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Keywords:

  • zebrafish;
  • spinal cord regeneration;
  • behavioral recovery after spinal cord lesion;
  • functional recovery;
  • axon re-growth;
  • neuron-intrinsic changes;
  • plasticity in the lesioned spinal cord;
  • spinal circuitry in developing zebrafish

Summary

This chapter contains sections titled:

  • Introduction

  • Behavioral Recovery After Spinal Cord Lesion

  • Anatomical Basis of Functional Recovery After Spinal Cord Transection

    • Descending Projections

      • Specificity of Axon Re-Growth from the Brainstem

    • Ascending Projections

  • Environmental Factors Influencing Axon Re-Growth

  • Neuron-Intrinsic Changes Associated with Axon Re-Growth

    • Expression of Growth-Associated Genes

    • Influence of the Level of Axotomy on the Regenerative Response

  • Evidence for Plasticity in the Lesioned Spinal Cord

  • Analysis of Spinal Circuitry in Developing Zebrafish

  • In-Vivo Approaches to the Study of Regeneration in Zebrafish

    • Functional Studies of Spinal Cord Regeneration in Adult Zebrafish

    • Use of Transgenic Fish to Analyze Gene Regulation During Regeneration

  • Future Directions

  • Conclusions