Chapter 2. Intrinsic Factors Contributing to Axon Regeneration in the Mammalian Nervous System

  1. Dr. Catherina G. Becker and
  2. Dr. Thomas Becker
  1. Ferdinando Rossi

Published Online: 5 FEB 2007

DOI: 10.1002/9783527610365.ch2

Model Organisms in Spinal Cord Regeneration

Model Organisms in Spinal Cord Regeneration

How to Cite

Rossi, F. (2006) Intrinsic Factors Contributing to Axon Regeneration in the Mammalian Nervous System, in Model Organisms in Spinal Cord Regeneration (eds C. G. Becker and T. Becker), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527610365.ch2

Editor Information

  1. Centre for Neuroscience Research, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK

Author Information

  1. Rita Levi Montalcini Centre for Brain Repair, Department of Neuroscience, University of Turin, Corso Raffaello 30, 10125 Turin, Italy

Publication History

  1. Published Online: 5 FEB 2007
  2. Published Print: 15 DEC 2006

ISBN Information

Print ISBN: 9783527315048

Online ISBN: 9783527610365

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Keywords:

  • axon regeneration in the mammalian nervous system;
  • modes of axon growth;
  • developmental regulation of the intrinsic neuronal growth properties;
  • intrinsic mechanisms;
  • injury-derived regulation of the intrinsic neuronal growth properties;
  • growth control and experience-dependent plasticity in the CNS

Summary

This chapter contains sections titled:

  • Introduction

  • Modes of Axon Growth

  • Developmental Regulation of the Intrinsic Neuronal Growth Properties

    • Purely Intrinsic Mechanisms

    • Target-Derived Factors

    • Factors Acting Along the Axon

    • Factors Acting on the Cell Body

  • Injury-Derived Regulation of Intrinsic Neuronal Growth Properties

    • Negative Regulation by Injury-Associated Factors

    • Positive Regulation by Injury-Associated Factors

  • Procedures to Enhance Intrinsic Growth Potential

    • Conditioning Lesions

    • Pharmacological Stimulation

    • Overexpression of Neuronal Growth Genes

  • How Does Up-Regulation of Neuronal Growth Genes Override Environmental Inhibition?

  • Growth Control and Experience-Dependent Plasticity in the CNS