Chapter 3. Stimulating Intrinsic Growth Potential in Mammalian Neurons

  1. Dr. Catherina G. Becker and
  2. Dr. Thomas Becker
  1. Bhavna Ylera and
  2. Frank Bradke

Published Online: 5 FEB 2007

DOI: 10.1002/9783527610365.ch3

Model Organisms in Spinal Cord Regeneration

Model Organisms in Spinal Cord Regeneration

How to Cite

Ylera, B. and Bradke, F. (2006) Stimulating Intrinsic Growth Potential in Mammalian Neurons, in Model Organisms in Spinal Cord Regeneration (eds C. G. Becker and T. Becker), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527610365.ch3

Editor Information

  1. Centre for Neuroscience Research, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK

Author Information

  1. Max Planck Institute of Neurobiology, Axonal Growth and Regeneration, Am Klopferspitz 18, 82152 Martinsried, Germany

Publication History

  1. Published Online: 5 FEB 2007
  2. Published Print: 15 DEC 2006

ISBN Information

Print ISBN: 9783527315048

Online ISBN: 9783527610365

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Keywords:

  • stimulating intrinsic growth potential in mammalian neurons;
  • intrinsic and environmental factors influencing axonal growth;
  • neuronal age;
  • signaling pathways involved in influencing intrinsic regenerative growth potential;
  • identification of genes and proteins involved in axonal regeneration;
  • specific proteins involved in axonal regeneration

Summary

This chapter contains sections titled:

  • Introduction

  • Both Intrinsic and Environmental Factors Influence Axonal Growth

  • Intrinsic Growth Potential Depends on Neuronal Age

  • Signaling Pathways Involved in Influencing Intrinsic Regenerative Growth Potential

    • Role of cAMP in Axonal Regeneration

      • Therapeutic Strategies for CNS Repair Based on Stimulating Intrinsic Growth Potential of Neurons via the cAMP Pathway

    • Role of Conditioning Lesion in Axon Regeneration

      • The Conditioning Lesion Paradigm

    • Rho Signaling in Axon Regeneration

      • Role of PKC in Rho-Mediated Inhibition of Axon Growth

  • Identification of Genes and Proteins Involved in Axonal Regeneration

    • Genes Involved in Autodestruction and Neuroprotection

    • Cell Cycle Genes

    • Plasticity Genes

    • Spatiotemporal Alteration of Genes Involved in Cholesterol Metabolism, Apoptosis, Cell Cycle, and Inflammation

    • Late Changes in Gene Expression

  • Specific Proteins Involved in Axonal Regeneration

    • SPRR1A

    • Fibroblast Growth Factor-Inducible-14

    • GAP-43 and CAP-23

    • α7β1 Integrin

    • Retinoic Acid Receptor

  • Conclusions and Outlook