Chapter 6. Genetic Approaches to Spinal Locomotor Function in Mammals

  1. Dr. Catherina G. Becker and
  2. Dr. Thomas Becker
  1. Anna Vallstedt and
  2. Klas Kullander

Published Online: 5 FEB 2007

DOI: 10.1002/9783527610365.ch6

Model Organisms in Spinal Cord Regeneration

Model Organisms in Spinal Cord Regeneration

How to Cite

Vallstedt, A. and Kullander, K. (2006) Genetic Approaches to Spinal Locomotor Function in Mammals, in Model Organisms in Spinal Cord Regeneration (eds C. G. Becker and T. Becker), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527610365.ch6

Editor Information

  1. Centre for Neuroscience Research, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK

Author Information

  1. Department of Neuroscience, Unit of Developmental Genetics, Uppsala University, Box 587, 75123 Uppsala, Sweden

Publication History

  1. Published Online: 5 FEB 2007
  2. Published Print: 15 DEC 2006

ISBN Information

Print ISBN: 9783527315048

Online ISBN: 9783527610365



  • spinal locomotor function in mammals;
  • genetic approaches;
  • spinal cord neurons;
  • neuronal network;
  • neuronal circuit;
  • visualization of neurons;
  • emerging technologies;
  • interneurons;
  • functional studies


This chapter contains sections titled:

  • Introduction

    • The Spinal Cord Central Pattern Generator

    • Dissecting a Neuronal Network

  • Development of Spinal Cord Neurons

    • Origin of Ventral Spinal Cord Neurons

    • Function of Early Neuronal Classes

    • Creating Functional Diversity

  • Spinal Cord Neurons Involved in Locomotor Function

    • Location of the CPG

    • Motor Neurons

    • The Renshaw Cell

    • Interneurons Involved in Spinal Reflex Pathways

    • Excitatory Interneurons

    • Commissural Interneurons

  • Circuit Formation

    • Axon Guidance Molecules and Function of Neuronal Circuits

    • Neurotransmitter Phenotype During CPG Development

  • Emerging Technologies

    • Genetic Markers

    • Gene-Expression Initiatives

    • Creating Transgenics

    • The Combination of Cre-Expressing and Reporter Mice

    • The Principle of Reporter Mice

    • Visualization of Neurons

    • Visualization of Neuronal Connectivity

    • Visualization of Neuronal Activity

    • In-Vivo Imaging of Neuronal Populations

    • Functional Studies by Destruction of Neurons

    • Functional Studies Through Silencing of Neurotransmission

    • Functional Studies Through Activation of Neurons

  • Future Directions