Chapter 8. Regeneration in the Lamprey Spinal Cord

  1. Dr. Catherina G. Becker and
  2. Dr. Thomas Becker
  1. Michael I. Shifman,
  2. Li-Qing Jin and
  3. Michael E. Selzer

Published Online: 5 FEB 2007

DOI: 10.1002/9783527610365.ch8

Model Organisms in Spinal Cord Regeneration

Model Organisms in Spinal Cord Regeneration

How to Cite

Shifman, M. I., Jin, L.-Q. and Selzer, M. E. (2006) Regeneration in the Lamprey Spinal Cord, in Model Organisms in Spinal Cord Regeneration (eds C. G. Becker and T. Becker), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527610365.ch8

Editor Information

  1. Centre for Neuroscience Research, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK

Author Information

  1. Department of Neurology, David Mahoney Institute of Neurological Science, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA

Publication History

  1. Published Online: 5 FEB 2007
  2. Published Print: 15 DEC 2006

ISBN Information

Print ISBN: 9783527315048

Online ISBN: 9783527610365



  • non-mammalian models of spinal cord regeneration;
  • regeneration in the lamprey spinal cord;
  • evolutionary importance;
  • neuroscience research;
  • axonal regeneration;
  • intraneuronal mechanisms of axon regeneration;
  • axon-guidance molecules;
  • neuroanatomy;
  • cytoskeletal changes


This chapter contains sections titled:

  • Introduction

    • General Biology

    • Evolutionary Importance

    • Uses in Neuroscience Research

      • Neuroanatomy

      • Synaptic Transmission in the CNS

      • Pattern Generation

  • Axonal Regeneration

    • Background: Early Anatomic and Physiologic Studies

    • Demonstration of Functional Axon Regeneration

      • NIH Criteria

      • Evidence That the Experimental Lesion Disconnects Nerve Fibers

      • Anatomic Evidence That Regenerated Axons Bridge the Lesion and Make Junctional Contacts

      • Evidence That Regenerated Fibers Elicit Postjunctional Responses

      • Evidence That Changes in Function Derive from Regenerated Connections

    • Specificity of Regeneration

    • Heterogeneity of Axon Regenerative Ability

    • Intraneuronal Mechanisms of Axon Regeneration

      • Cytoskeletal Changes During Axon Retraction

      • Cytoskeletal Changes During Regeneration

    • Role of Axon-Guidance Molecules in Axon Regeneration in the Spinal Cord

      • Cloning and Sequencing of Axonal-Guidance Molecules from Lamprey CNS

      • Effect of Spinal Transection on Expression of Netrin and its Receptors

      • Expression Patterns of Semaphorins and Their Receptors

      • Effect of Spinal Cord Transection on Semaphorin Expression

      • Evidence from Other Species for Involvement of Guidance Molecules in Axon Regeneration

      • Possible Mechanisms of Involvement of Guidance Molecules in Regeneration

  • Conclusions: Where Lampreys Fit Into the Study of Regeneration