Chapter 1. Mass Spectrometry in Bioanalysis – Methods, Principles and Instrumentation

  1. Prof. Dr. Klaus T. Wanner and
  2. Dr. Georg Höfner
  1. Gérard Hopfgartner

Published Online: 24 MAY 2007

DOI: 10.1002/9783527610907.ch1

Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery

Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery

How to Cite

Hopfgartner, G. (2007) Mass Spectrometry in Bioanalysis – Methods, Principles and Instrumentation, in Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery (eds K. T. Wanner and G. Höfner), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527610907.ch1

Editor Information

  1. Ludwig-Maximilians-University Munich, Department of Pharmacy, Center of Drug Research, Butenandtstr., 81377 Munich, Germany

Author Information

  1. Life Sciences Mass Spectrometry, School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, 20 Boulevard d'Yvoy, CH-1211 Geneva 4, Switzerland

Publication History

  1. Published Online: 24 MAY 2007
  2. Published Print: 23 FEB 2007

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof. Dr. Raimund Mannhold3,
  2. Prof. Dr. Hugo Kubinyi4 and
  3. Prof. Dr. Gerd Folkers5

Series Editor Information

  1. 3

    Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany

  2. 4

    Donnersbergerstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 5

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527314560

Online ISBN: 9783527610907

SEARCH

Keywords:

  • mass spectrometry;
  • applications in bioanalysis;
  • methods;
  • principles;
  • instrumentation;
  • ionization techniques;
  • mass analyzers;
  • ion detectors

Summary

This chapter contains sections titled:

  • Introduction

  • Fundamentals

  • Ionization Techniques

    • Electron Impact and Chemical Ionization

    • Atmospheric Pressure Ionization

      • Electrospray

      • Atmospheric Pressure Chemical Ionization

      • Photoionization

      • Multiple Ionization Source

      • Desorption Electrospray and Direct Analysis in Real Time

    • Matrix Assisted Laser Desorption Ionization

  • Mass Analyzers

    • Quadrupole Analyzers

    • Triple Quadrupole Mass Analyzer

    • Ion Trap Mass Spectrometry

    • Triple Quadrupole Linear Ion Trap

    • Time of Flight Mass Spectrometry

    • Fourier Transform Mass Spectrometry

      • Fourier Transform–Ion Cyclotron Resonance Mass Spectrometry

      • Orbitrap Mass Spectrometer

  • Ion Detectors

  • Practical Aspects and Applications in Bioanalysis

    • Introduction

    • Quantitative Analysis in Biological Matrices

    • Drug Metabolism

    • Analysis of Proteins

  • Perspectives

  • Common Definitions and Abbreviations