Chapter 13. Mass Spectrometry in Early Pharmacokinetic Investigations

  1. Prof. Dr. Klaus T. Wanner and
  2. Dr. Georg Höfner
  1. Walter A. Korfmacher

Published Online: 24 MAY 2007

DOI: 10.1002/9783527610907.ch13

Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery

Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery

How to Cite

Korfmacher, W. A. (2007) Mass Spectrometry in Early Pharmacokinetic Investigations, in Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery (eds K. T. Wanner and G. Höfner), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527610907.ch13

Editor Information

  1. Ludwig-Maximilians-University Munich, Department of Pharmacy, Center of Drug Research, Butenandtstr., 81377 Munich, Germany

Author Information

  1. Exploratory Drug Metabolism, Department of Drug Metabolism and Pharmacokinetics, Schering–Plough Research Institute, Kenilworth, NJ 07033, USA

Publication History

  1. Published Online: 24 MAY 2007
  2. Published Print: 23 FEB 2007

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof. Dr. Raimund Mannhold3,
  2. Prof. Dr. Hugo Kubinyi4 and
  3. Prof. Dr. Gerd Folkers5

Series Editor Information

  1. 3

    Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany

  2. 4

    Donnersbergerstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 5

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527314560

Online ISBN: 9783527610907

SEARCH

Keywords:

  • mass spectrometry in early pharmacokinetics;
  • HPLC-MS/MS overview;
  • in vitro applications;
  • in vivo applications;
  • rapid method development;
  • increasing throughput in HPLC-MS/MS;
  • matrix effects;
  • discovery PK assay rule;
  • new technology in LC-MS

Summary

This chapter contains sections titled:

  • Introduction

  • HPLC-MS/MS Overview

  • In Vitro Applications

  • In Vivo Applications

  • Rapid Method Development

  • Increasing Throughput in HPLC-MS/MS

  • Matrix Effects

  • Discovery PK Assay Rules

  • New Technology in LC-MS

  • Conclusion