Chapter 9. Tethering: Fragment-Based Drug Discovery by Mass Spectrometry

  1. Prof. Dr. Klaus T. Wanner and
  2. Dr. Georg Höfner
  1. Mark T. Cancilla and
  2. Daniel A. Erlanson

Published Online: 24 MAY 2007

DOI: 10.1002/9783527610907.ch9

Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery

Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery

How to Cite

Cancilla, M. T. and Erlanson, D. A. (2007) Tethering: Fragment-Based Drug Discovery by Mass Spectrometry, in Mass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery (eds K. T. Wanner and G. Höfner), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527610907.ch9

Editor Information

  1. Ludwig-Maximilians-University Munich, Department of Pharmacy, Center of Drug Research, Butenandtstr., 81377 Munich, Germany

Author Information

  1. Sunesis Pharmaceuticals, Inc., 341 Oyster Point Boulevard, South San Francisco, CA 94080, USA

Publication History

  1. Published Online: 24 MAY 2007
  2. Published Print: 23 FEB 2007

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof. Dr. Raimund Mannhold3,
  2. Prof. Dr. Hugo Kubinyi4 and
  3. Prof. Dr. Gerd Folkers5

Series Editor Information

  1. 3

    Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany

  2. 4

    Donnersbergerstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 5

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527314560

Online ISBN: 9783527610907

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Keywords:

  • fragment-based drug discovery by mass spectrometry;
  • technique;
  • advantages;
  • finding fragments;
  • caspase-3;
  • caspase-1

Summary

This chapter contains sections titled:

  • Introduction

  • Reduction to Practice

    • Technique

    • Advantages

  • Finding Fragments: Thymidylate Synthase Proof of Principle

  • Finding and Linking Fragments in One Step: Tethering with Extenders

    • Caspase-3

    • Caspase-1

  • Conclusions