Chapter 1. Development of the Blood-Brain Interface

  1. Prof. Dr. Rolf Dermietzel2,
  2. Prof. Dr. David C. Spray3 and
  3. Prof. Dr. Maiken Nedergaard4
  1. Britta Engelhardt

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Engelhardt, B. (2006) Development of the Blood-Brain Interface, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch1

Editor Information

  1. 2

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 3

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 4

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. Theodor Kocher Institute, University of Bern, Freiestrasse 1, 3012 Bern, Switzerland

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225

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Keywords:

  • ontogeny;
  • blood-brain barrier (BBB);
  • development of blood-brain interface;
  • development of CNS vasculature;
  • differentiation;
  • maintenance

Summary

This chapter contains sections titled:

  • Introduction

  • Pioneering Research on the Blood-Brain Barrier

  • The Mature Blood-Brain Interface

  • Development of the CNS Vasculature

  • Differentiation of the Blood-Brain Barrier

    • Permeability

    • Transport Systems and Markers

    • Extracellular Matrix

    • Putative Inductive Mechanisms

  • Maintenance of the Blood-Brain Barrier

  • Outlook

  • References