Chapter 10. The Role of Fibroblast Growth Factor 2 in the Establishment and Maintenance of the Blood-Brain Barrier

  1. Prof. Dr. Rolf Dermietzel2,
  2. Prof. Dr. David C. Spray3 and
  3. Prof. Dr. Maiken Nedergaard4
  1. Bernhard Reuss

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch10

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Reuss, B. (2006) The Role of Fibroblast Growth Factor 2 in the Establishment and Maintenance of the Blood-Brain Barrier, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch10

Editor Information

  1. 2

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 3

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 4

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. Center for Anatomy, University of Göttingen, Kreuzbergring 36, 37075 Göttingen, Germany

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225

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Keywords:

  • hormonal control;
  • enzymatic control;
  • brain vessels;
  • role of fibroblast growth factor 2;
  • establishment of blood-brain barrier;
  • maintenance of blood-brain barrier;
  • expression of FGF-2 in astrocytes;
  • expression of FGF-2 in endothelial cells;
  • rodent brain

Summary

This chapter contains sections titled:

  • Introduction

  • Role of FGF-2 in the Regulation of BBB Formation

    • Expression of FGF-2 in Astrocytes and Endothelial Cells of the Rodent Brain

    • Induction of BBB Properties in Endothelial Cells by Soluble Factors

    • Indirect Astrocyte Mediated Effects Seem to Play a Role in FGF-2-Dependent Changes in Endothelial Cell Differentiation

    • Involvement of FGF-2 in the Regulation of BBB Properties in the Pathologically Altered Brain

  • Future Perspectives

  • References