Chapter 12. Insulin and the Blood-Brain Barrier

  1. Prof. Dr. Rolf Dermietzel3,
  2. Prof. Dr. David C. Spray4 and
  3. Prof. Dr. Maiken Nedergaard5
  1. William A. Banks1 and
  2. Wee Shiong Lim2

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch12

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Banks, W. A. and Lim, W. S. (2006) Insulin and the Blood-Brain Barrier, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch12

Editor Information

  1. 3

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 4

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 5

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. 1

    Veterans Affairs Medical Center, 915 N. Grand Boulevard, St. Louis, MO 63106, USA

  2. 2

    Department of Geriatric Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Republic of Singapore

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225



  • hormonal control;
  • enzymatic control;
  • brain vessels;
  • insulin and blood-brain barrier;
  • permeability of BBB to insulin;
  • pathophysiology of insulin transport;
  • insulin resistance;
  • inflammatory states;
  • insulin and Alzheimer's disease


This chapter contains sections titled:

  • Introduction

    • Early Studies

    • Debates Related to the Question of Permeability of the BBB to Insulin

    • Does Insulin Cross the BBB? The Middle Years

    • Insulin, the BBB, and Pathophysiology: The Past Decade

  • Pathophysiology of Insulin Transport

    • Insulin, Obesity, and Diabetes

    • Insulin Resistance and Inflammatory States

    • Insulin and Alzheimer's Disease

  • References