Chapter 13. Glucocorticoid Hormones and Estrogens: Their Interaction with the Endothelial Cells of the Blood-Brain Barrier

  1. Prof. Dr. Rolf Dermietzel2,
  2. Prof. Dr. David C. Spray3 and
  3. Prof. Dr. Maiken Nedergaard4
  1. Jean-Bernard Dietrich

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch13

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Dietrich, J.-B. (2006) Glucocorticoid Hormones and Estrogens: Their Interaction with the Endothelial Cells of the Blood-Brain Barrier, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch13

Editor Information

  1. 2

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 3

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 4

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. Inserm U 575, Université Louis Pasteur, 5, rue B. Pascal, 67084 Strasbourg, France

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225

SEARCH

Keywords:

  • hormonal control;
  • enzymatic control;
  • brain vessels;
  • glucocorticoid hormones;
  • estrogens;
  • endothelial cells of blood-brain barrier;
  • adhesion molecules regulated by estrogens in endothelial cells

Summary

This chapter contains sections titled:

  • Introduction

  • Glucocorticoids and the Endothelial Cells of the BBB

    • Mechanisms of Action of Glucocorticoids

    • Glucocorticoids and Inflammation

    • Regulation of Adhesion Molecules Expression by GC in Endothelial Cells

    • Effects of GC on Leukocyte-Endothelial Cell Interactions

    • Glucocorticoids, Cerebral Endothelium and Multiple Sclerosis

  • Estrogens and the Endothelial Cells of the BBB

    • Mechanisms of Action of Estrogens

    • Endothelial Cells as Targets of Estrogens

    • Adhesion Molecules are Regulated by Estrogens in Endothelial Cells

    • Estrogens and Experimental Autoimmune Encephalomyelitis

  • Conclusions and Perspectives

  • References