Chapter 14. Metalloproteinases and the Brain Microvasculature

  1. Prof. Dr. Rolf Dermietzel3,
  2. Prof. Dr. David C. Spray4 and
  3. Prof. Dr. Maiken Nedergaard5
  1. Dorothee Krause1 and
  2. Christina Lohmann2

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch14

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Krause, D. and Lohmann, C. (2006) Metalloproteinases and the Brain Microvasculature, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch14

Editor Information

  1. 3

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 4

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 5

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. 1

    Institute of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 2

    Discovery DMPK&BA, AstraZeneca R&D Lund, Scheelevägen 8, 22187 Lund, Sweden

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225

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Keywords:

  • hormonal control;
  • enzymatic control;
  • brain vessels;
  • metalloproteinases;
  • brain microvasculature;
  • cerebral endothelial cells;
  • perivascular cells;
  • blood-liquor barrier;
  • brain diseases

Summary

This chapter contains sections titled:

  • Introduction

  • Metalloproteinases in Brain Microvessels: Types and Functions

  • Cerebral Endothelial Cells and Metalloproteinases

  • Perivascular Cells and Metalloproteinases

    • Pericytes

    • Astrocytes and Microglia

  • Metalloproteinases and the Blood-Liquor Barrier

  • Metalloproteinases and Brain Diseases

    • Metalloproteinases and Cerebral Ischemia

    • Metalloproteinases and Brain Tumors

    • Metalloproteinases and Multiple Sclerosis

    • MMPs and Migraine

  • Conclusion

  • References