Chapter 19. The Blood-Brain Barrier: Roles of the Multidrug Resistance Transporter P-Glycoprotein

  1. Prof. Dr. Rolf Dermietzel3,
  2. Prof. Dr. David C. Spray4 and
  3. Prof. Dr. Maiken Nedergaard5
  1. Sandra Turcotte1,
  2. Michel Demeule1,
  3. Anthony Régina1,
  4. Chantal Fournier1,
  5. Julie Jodoin1,
  6. Albert Moghrabi2 and
  7. Richard Béliveau1

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch19

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Turcotte, S., Demeule, M., Régina, A., Fournier, C., Jodoin, J., Moghrabi, A. and Béliveau, R. (2006) The Blood-Brain Barrier: Roles of the Multidrug Resistance Transporter P-Glycoprotein, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch19

Editor Information

  1. 3

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 4

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 5

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. 1

    Département de Chimie-Biochimie, Université du Québec à Montréal, C.P. 8888, Succursale Centre-ville, Montréal, H3C 3P8, Canada

  2. 2

    Centre de Cancérologie Charles Bruneau, Université du Québec à Montréal, 3175 Chemin Côte-Ste-Catherine, Montréal, H3T 1C5, Canada

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225

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Keywords:

  • drug delivery to the brain;
  • blood-brain barrier;
  • multidrug resistance transporter P-glycoprotein;
  • localization of P-glycoprotein (P-gp);
  • transport activity of P-gp;
  • polymorphisms of P-gp;
  • role of P-gp at the BBB

Summary

This chapter contains sections titled:

  • Introduction

  • The Multidrug Transporter P-Glycoprotein

    • P-gp Isoforms

    • Structure

    • P-gp Substrates

  • Localization and Transport Activity of P-gp in the CNS

    • Normal Brain

    • Brain Diseases

      • Malignant Brain Tumors

      • Brain Metastases

    • Expression of Other ABC Transporters at the BBB

    • Subcellular Localization of P-gp

  • Polymorphisms of P-gp

    • MDR1 Polymorphisms at the BBB

    • MDR1 Polymorphism and Brain Pathologies

  • Role of P-gp at the BBB

    • Protection Against Xenobiotics

    • Secretion of Endogenous Brain Substrates and Endothelial Secretion

    • Caveolar Trafficking

  • Conclusions

  • References