Chapter 2. Brain Angiogenesis and Barriergenesis

  1. Prof. Dr. Rolf Dermietzel2,
  2. Prof. Dr. David C. Spray3 and
  3. Prof. Dr. Maiken Nedergaard4
  1. Jeong Ae Park,
  2. Yoon Kyung Choi,
  3. Sae-Won Lee and
  4. Kyu-Won Kim

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch2

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Park, J. A., Choi, Y. K., Lee, S.-W. and Kim, K.-W. (2006) Brain Angiogenesis and Barriergenesis, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch2

Editor Information

  1. 2

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 3

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 4

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul, 151–742, Korea

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225



  • ontogeny;
  • blood-brain barrier (BBB);
  • brain angiogenesis;
  • barriergenesis;
  • brain oxygenation;
  • src-suppressed C kinase substrate;
  • barriergenic factors;
  • perivascular astrocytes;
  • pericytes


This chapter contains sections titled:

  • Introduction

  • Brain Angiogenesis

    • Hypoxia-Regulated HIF-1 in the Development of the Brain

    • Hypoxia-Inducible Factor

    • Hypoxia-Induced VEGF

    • Other Neuroglia-Derived Angiogenic Factors

  • Oxygenation in the Brain: Brain Barriergenesis

    • Cellular and Molecular Responses Following Brain Oxygenation

    • Role of src-Suppressed C Kinase Substrate in the Induction of Barriergenesis

    • Barriergenic Factors in Perivascular Astrocytes and Pericytes Following Brain Oxygenation

  • Perspectives

  • References