Chapter 20. Targeting of Neuropharmaceuticals by Chemical Delivery Systems

  1. Prof. Dr. Rolf Dermietzel3,
  2. Prof. Dr. David C. Spray4 and
  3. Prof. Dr. Maiken Nedergaard5
  1. Nicholas Bodor1 and
  2. Peter Buchwald2

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch20

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Bodor, N. and Buchwald, P. (2006) Targeting of Neuropharmaceuticals by Chemical Delivery Systems, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch20

Editor Information

  1. 3

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 4

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 5

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. 1

    Center for Drug Discovery, University of Florida, PO Box 100497, Gainesville, FL 32610-0497, USA

  2. 2

    IVAX Research, Inc., 4400 Biscayne Boulevard, Miami, FL 33137, USA

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225

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Keywords:

  • drug delivery to the brain;
  • targeting of neuropharmaceuticals;
  • chemical delivery systems;
  • blood-brain barrier;
  • brain-targeted drug delivery;
  • molecular packaging

Summary

This chapter contains sections titled:

  • Introduction

  • The Blood-Brain Barrier

    • Structural Aspects

    • Enzymatic and Transporter-Related Aspects

  • Brain-Targeted Drug Delivery

    • Lipophilicity and Its Role in CNS Entry

    • Quantifying Brain-Targeting: Site-Targeting Index and Targeting Enhancement Factors

  • Chemical Delivery Systems

  • Brain-Targeting CDSs

    • Design Principles

    • Zidovudine-CDS

    • Ganciclovir-CDS

    • Benzylpenicillin-CDS

    • Estradiol-CDS

    • Cyclodextrin Complexes

  • Molecular Packaging

    • Leu-Enkephalin Analogs

    • TRH Analogs

    • Kyotorphin Analogs

    • Brain-Targeted Redox Analogs

  • References