Chapter 21. Drug Delivery to the Brain by Internalizing Receptors at the Blood-Brain Barrier

  1. Prof. Dr. Rolf Dermietzel3,
  2. Prof. Dr. David C. Spray4 and
  3. Prof. Dr. Maiken Nedergaard5
  1. Pieter J. Gaillard1,
  2. Corine C. Visser2 and
  3. Albertus (Bert) G. de Boer2

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch21

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Gaillard, P. J., Visser, C. C. and de Boer, A. G. (2006) Drug Delivery to the Brain by Internalizing Receptors at the Blood-Brain Barrier, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch21

Editor Information

  1. 3

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 4

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 5

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. 1

    to-BBB technologies BV, Bio Science Park Leiden, Gorlaeus Laboratories, LACDR Facilities-FCOL, Einsteinweg 55, 2333 CC, Leiden, The Netherlands

  2. 2

    Blood-Brain Barrier Research Group, Division of Pharmacology, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225

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Keywords:

  • drug delivery to the brain;
  • internalizing receptors at blood-brain barrier;
  • transport opportunities;
  • targeting strategies to the brain;
  • receptor-mediated drug delivery;
  • transferrin receptor;
  • insulin receptor;
  • LRP1 and LRP2 receptors;
  • diphtheria toxin receptor

Summary

This chapter contains sections titled:

  • Introduction

  • Blood-Brain Barrier Transport Opportunities

  • Drug Delivery and Targeting Strategies to the Brain

  • Receptor-Mediated Drug Delivery to the Brain

  • Transferrin Receptor

  • Insulin Receptor

  • LRP1 and LRP2 Receptors

  • Diphtheria Toxin Receptor

  • Conclusions

  • References