Chapter 22. Blood-Brain Transfer and Metabolism of Oxygen

  1. Prof. Dr. Rolf Dermietzel2,
  2. Prof. Dr. David C. Spray3 and
  3. Prof. Dr. Maiken Nedergaard4
  1. Albert Gjedde

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch22

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Gjedde, A. (2006) Blood-Brain Transfer and Metabolism of Oxygen, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch22

Editor Information

  1. 2

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 3

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 4

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. Pathophysiology and Experimental Tomography Center and Center of Functionally Integrative Neuroscience, Aarhus University Hospital, 44 Norrebrogade, 8000 Aarhus, Denmark

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225

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Keywords:

  • vascular perfusion;
  • blood-brain transfer;
  • metabolism of oxygen;
  • transfer of oxygen;
  • oxygen in brain tissue;
  • flow-metabolism coupling of oxygen;
  • limits to oxygen supply

Summary

This chapter contains sections titled:

  • Introduction

  • Blood-Brain Transfer of Oxygen

    • Capillary Model of Oxygen Transfer

    • Compartment Model of Oxygen Transfer

  • Oxygen in Brain Tissue

    • Cytochrome Oxidation

    • Mitochondrial Oxygen Tension

      • Distributed Model of Tissue and Mitochondrial Oxygen

      • Compartment Models of Tissue and Mitochondrial Oxygen

  • Flow-Metabolism Coupling of Oxygen

  • Limits to Oxygen Supply

    • Distributed Model of Insufficient Oxygen Delivery

    • Compartment Model of Insufficient Oxygen Delivery

  • Experimental Results

    • Brain Tissue and Mitochondrial Oxygen Tensions

    • Flow-Metabolism Coupling

    • Ischemic Limits of Oxygen Diffusibility

  • References