Chapter 25. Stroke and the Blood-Brain Interface

  1. Prof. Dr. Rolf Dermietzel2,
  2. Prof. Dr. David C. Spray3 and
  3. Prof. Dr. Maiken Nedergaard4
  1. Marilyn J. Cipolla

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch25

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Cipolla, M. J. (2006) Stroke and the Blood-Brain Interface, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch25

Editor Information

  1. 2

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 3

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 4

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. Department of Neurology, University of Vermont, 89 Beaumont Avenue, Given C454, Burlington, VT 05405, USA

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225



  • disease-related response;
  • stroke;
  • blood-brain interface;
  • brain edema formation;
  • astrocytes;
  • mediating edema;
  • ischemia;
  • cellular regulation;
  • cerebrovascular permeability;
  • reperfusion injury;
  • transcellular transport;
  • mediators of EC permeability;
  • hyperglycemic stroke;
  • hemodynamic changes


This chapter contains sections titled:

  • Introduction

  • Brain Edema Formation During Stroke

    • Cytotoxic Versus Vasogenic Edema

  • Role of Astrocytes in Mediating Edema During Ischemia

    • Aquaporins and Cerebral Edema During Ischemia

  • Cellular Regulation of Cerebrovascular Permeability

    • Role of Actin

    • Ischemia and Hypoxia Effects on EC Actin and Permeability

  • Reperfusion Injury

    • Nitric Oxide and Other Reactive Oxygen Species as Mediators of EC Permeability During Ischemia And Reperfusion

    • Thresholds of Injury

  • Transcellular Transport as a Mechanism of BBB Disruption During Ischemia

  • Mediators of EC Permeability During Ischemia

  • Hyperglycemic Stroke

    • Role of PKC Activity in Mediating Enhanced BBB Permeability During Hyperglycemic Stroke

  • Hemodynamic Changes During Ischemia and Reperfusion and its Role in Cerebral Edema

  • References