Chapter 27. Human Parasitic Disease in the Context of the Blood-Brain Barrier – Effects, Interactions, and Transgressions

  1. Prof. Dr. Rolf Dermietzel5,
  2. Prof. Dr. David C. Spray6 and
  3. Prof. Dr. Maiken Nedergaard7
  1. Mahalia S. Desruisseaux1,
  2. Louis M. Weiss2,
  3. Herbert B. Tanowitz2,
  4. Adam Mott3 and
  5. Danny A. Milner4

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch27

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Desruisseaux, M. S., Weiss, L. M., Tanowitz, H. B., Mott, A. and Milner, D. A. (2007) Human Parasitic Disease in the Context of the Blood-Brain Barrier – Effects, Interactions, and Transgressions, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch27

Editor Information

  1. 5

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 6

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 7

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. 1

    Montefiore Medical Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA

  2. 2

    Division of Infectious Diseases, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA

  3. 3

    Department of Immunology & Infectious Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA

  4. 4

    Harvard Medical School, Department of Pathology, Brigham & Women's Hospital, 75 Francis Street, Amory 3, Boston, MA 02115, USA

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225

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Keywords:

  • disease-related response;
  • human parasitic disease;
  • blood-brain barrier;
  • effects;
  • interactions;
  • transgressions;
  • malaria;
  • trypanosomiasis;
  • toxoplasmosis

Summary

This chapter contains sections titled:

  • Introduction

  • Malaria: The Plasmodium berghei Mouse Model and the Severe Falciparum Malaria in Man

    • Upregulation of Intercellular Adhesion Molecules

    • Secretion of TNF-α

    • Microglial Activation

    • Vascular Damage

  • Trypanosomiasis: African and American Parasites of Two Distinct Flavors

    • CNS Pathology in African Trypanosomiasis

    • Cytokines and Endothelial Cell Activation

    • Astrocytosis and Microglial Cell Activation

      • Nitric Oxide

    • American Trypanosomiasis (Chagas' Disease)

  • Toxoplasmosis: Transgression, Quiescence, and Destructive Infections

  • Conclusion

  • References