Chapter 28. The Blood Retinal Interface: Similarities and Contrasts with the Blood-Brain Interface

  1. Prof. Dr. Rolf Dermietzel2,
  2. Prof. Dr. David C. Spray3 and
  3. Prof. Dr. Maiken Nedergaard4
  1. Tailoi Chan-Ling

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch28

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Chan-Ling, T. (2006) The Blood Retinal Interface: Similarities and Contrasts with the Blood-Brain Interface, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch28

Editor Information

  1. 2

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 3

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 4

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. Department of Anatomy, Institute for Biomedical Research, University of Sydney, Sydney, NSW 2006, Australia

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225

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Keywords:

  • disease-related response;
  • blood retinal interface;
  • inner BRB (blood-retinal barrier);
  • outer BRB;
  • choroidal vasculature;
  • intraretinal blood vessels;
  • BRB properties;
  • pericytes;
  • membrane proteins;
  • tight junctions;
  • occluding;
  • claudin-1;
  • clinical determination of blood-retinal barrier;
  • experimental determination of blood-retinal barrier

Summary

This chapter contains sections titled:

  • Introduction

  • The Inner and Outer BRB

  • The Choroidal Vasculature

  • Characteristics of Intraretinal Blood Vessels

  • Ensheathment and Induction of the Inner BRB by Astrocytes and Müller Glia

  • BRB Properties of Newly Formed Vessels

  • Pericytes and the BRB

  • Membrane Proteins of Tight Junctions

  • Localization of Occludin and Claudin-1 to Tight Junctions of Retinal Vascular Endothelial Cells

  • Expression of Occludin by RPE Cells and Lack of Occludin Expression by Choroidal Vessels

  • Inherent Weakness of the BRB and Existence of Resident MHC Class II+ Cells Predisposes the Optic Nerve Head to Inflammatory Attack

    • Compromised BBB Where CNS Meets Peripheral Vascular Bed

  • Clinical and Experimental Determination of the Blood-Retinal Barrier

  • Conclusions

  • References