Chapter 28. The Blood Retinal Interface: Similarities and Contrasts with the Blood-Brain Interface
- Prof. Dr. Rolf Dermietzel2,
- Prof. Dr. David C. Spray3,
- Prof. Dr. Maiken Nedergaard4
Published Online: 31 MAY 2007
DOI: 10.1002/9783527611225.ch28
Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1
Additional Information
How to Cite
Chan-Ling, T. (2007) The Blood Retinal Interface: Similarities and Contrasts with the Blood-Brain Interface, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch28
Editor Information
- 2
Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany
- 3
Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA
- 4
School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Publication History
- Published Online: 31 MAY 2007
- Published Print: 20 FEB 2006
ISBN Information
Print ISBN: 9783527310883
Online ISBN: 9783527611225
- Summary
- Chapter
- References
Keywords:
- disease-related response;
- blood retinal interface;
- inner BRB (blood-retinal barrier);
- outer BRB;
- choroidal vasculature;
- intraretinal blood vessels;
- BRB properties;
- pericytes;
- membrane proteins;
- tight junctions;
- occluding;
- claudin-1;
- clinical determination of blood-retinal barrier;
- experimental determination of blood-retinal barrier
Summary
This chapter contains sections titled:
Introduction
The Inner and Outer BRB
The Choroidal Vasculature
Characteristics of Intraretinal Blood Vessels
Ensheathment and Induction of the Inner BRB by Astrocytes and Müller Glia
BRB Properties of Newly Formed Vessels
Pericytes and the BRB
Membrane Proteins of Tight Junctions
Localization of Occludin and Claudin-1 to Tight Junctions of Retinal Vascular Endothelial Cells
Expression of Occludin by RPE Cells and Lack of Occludin Expression by Choroidal Vessels
Inherent Weakness of the BRB and Existence of Resident MHC Class II+ Cells Predisposes the Optic Nerve Head to Inflammatory Attack
Compromised BBB Where CNS Meets Peripheral Vascular Bed
Clinical and Experimental Determination of the Blood-Retinal Barrier
Conclusions
References