Chapter 4. The Endothelial Frontier

  1. Prof. Dr. Rolf Dermietzel2,
  2. Prof. Dr. David C. Spray3 and
  3. Prof. Dr. Maiken Nedergaard4
  1. Hartwig Wolburg

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch4

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Wolburg, H. (2006) The Endothelial Frontier, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch4

Editor Information

  1. 2

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 3

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 4

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. Institute of Pathology, University of Tübingen, Liebermeisterstrasse 8, 72076 Tübingen, Germany

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225

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Keywords:

  • cells of blood-brain interface;
  • endothelial frontier;
  • brain capillary endothelial cell;
  • endothelial structures;
  • transendothelial permeability;
  • tight junctions;
  • caveolae;
  • transporters;
  • neuroglio-vascular complex

Summary

This chapter contains sections titled:

  • Introduction

  • The Brain Capillary Endothelial Cell

  • Endothelial Structures Regulating Transendothelial Permeability

    • Tight Junctions

      • Morphology of Tight Junctions

      • Molecular Biology of Tight Junctions

    • Caveolae

    • Transporters in the Blood-Brain Barrier Endothelium

  • Brief Consideration of the Neuroglio-Vascular Complex

  • Conclusions

  • References