Chapter 6. Brain Macrophages: Enigmas and Conundrums

  1. Prof. Dr. Rolf Dermietzel3,
  2. Prof. Dr. David C. Spray4 and
  3. Prof. Dr. Maiken Nedergaard5
  1. Frederic Mercier1,
  2. Sebastien Mambie1 and
  3. Glenn I. Hatton2

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch6

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Mercier, F., Mambie, S. and Hatton, G. I. (2006) Brain Macrophages: Enigmas and Conundrums, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch6

Editor Information

  1. 3

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 4

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 5

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. 1

    Pacific Biomedical Research Center, University of Hawaii, 1993 East-West Road, Honolulu, HI 96822, USA

  2. 2

    Department of Cell Biology and Neuroscience, University of California, Riverside, 1208 Spieth Hall, Riverside, CA 92521, USA

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225



  • cells of blood-brain interface;
  • brain macrophages;
  • different types;
  • different locations;
  • migration;
  • fast renewal;
  • functions;
  • architects of CNS throughout adulthood


This chapter contains sections titled:

  • Introduction

  • Different Types and Locations of Brain Macrophages

    • Macrophage Structure and Ultrastructure

      • Perivascular Macrophages

      • Meningeal Macrophages

      • Dendritic Cells

      • Ventricular Macrophages

    • Immunotyping by Cell Surface Antigens

    • Macrophages Contact Basal Laminae

    • Network of Macrophages Through the Brain

  • Migration of Brain Macrophages

  • Fast Renewal of Brain Macrophages

  • Functions

    • Known Functions of Brain Macrophages

      • Phagocytosis

      • Immune Function

      • Production of Growth Factors, Cytokines, and Chemokines

      • Production and Degradation of the Extracellular Matrix

      • Repair After Injury

    • Potential Functions of Brain Macrophages

      • Interactions with Meningeal/Vascular Cells, Neurons, and Astrocytes

      • Do Macrophages Govern the Neural Stem Cell Niche in Adulthood?

      • Role of Macrophages in CNS Angiogenesis

      • Role of Macrophages in CNS Plasticity

  • Conclusion: Macrophages as Architects of the CNS Throughout Adulthood

  • References