Chapter 7. The Microglial Component

  1. Prof. Dr. Rolf Dermietzel3,
  2. Prof. Dr. David C. Spray4 and
  3. Prof. Dr. Maiken Nedergaard5
  1. Ingo Bechmann1,
  2. Angelika Rappert1,
  3. Josef Priller2 and
  4. Robert Nitsch1

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch7

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Bechmann, I., Rappert, A., Priller, J. and Nitsch, R. (2006) The Microglial Component, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch7

Editor Information

  1. 3

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 4

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 5

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. 1

    Institute of Cell Biology and Neurobiology, Charité University Hospital Berlin, Schumannstrasse 20/21, 10098 Berlin, Germany

  2. 2

    Department of Psychiatry, Charité University Hospital Berlin, Schumannstrasse 20/21, 10098 Berlin, Germany

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225

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Keywords:

  • cells of blood-brain interface;
  • microglia;
  • intrinsic immune sensor cells of CNS;
  • terminology;
  • turnover of brain mononuclear cells;
  • microglial impact on BBB function

Summary

This chapter contains sections titled:

  • Microglia: Intrinsic Immune Sensor Cells of the CNS

    • Development

    • Microglial Activation

    • Antigen Presentation/Cytotoxicity

  • Terminology: Subtypes and Their Location in Regard to Brain Vessels

    • Perivascular Macrophages

    • Juxtavascular and Other Microglia

  • Turnover of Brain Mononuclear Cells by Precursor Recruitment Across the BBB

    • Perivascular Cells

    • Microglia

    • Turnover Used by “Trojan Horses”

  • Microglial Impact on BBB Function

    • Concept of the BBB

    • Chemokines – an Overview

    • GAG/Duffy

    • Chemokine Expression in the CNS

    • CCL2 and CCR2

    • CCL3 and CCL5

    • CXCR3 and CXCL10

    • Microglia-Endothelial Cell Dialogue

    • Microglial Effects on Tight Junctions

  • Concluding Remarks

  • References