Chapter 9. Responsive Astrocytic Endfeet: The Role of AQP4 in BBB Development and Functioning

  1. Prof. Dr. Rolf Dermietzel4,
  2. Prof. Dr. David C. Spray5 and
  3. Prof. Dr. Maiken Nedergaard6
  1. Grazia P. Nicchia1,
  2. Beatrice Nico2,
  3. Laura M. A. Camassa1,
  4. Maria G. Mola1,
  5. Domenico Ribatti2,
  6. David C. Spray5,
  7. Alejandra Bosco5,
  8. Maria Svelto1 and
  9. Antonio Frigeri3

Published Online: 31 MAY 2007

DOI: 10.1002/9783527611225.ch9

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1

How to Cite

Nicchia, G. P., Nico, B., Camassa, L. M. A., Mola, M. G., Ribatti, D., Spray, D. C., Bosco, A., Svelto, M. and Frigeri, A. (2007) Responsive Astrocytic Endfeet: The Role of AQP4 in BBB Development and Functioning, in Blood-Brain Barriers: From Ontogeny to Artificial Interfaces, Volume 1 (eds R. Dermietzel, D. C. Spray and M. Nedergaard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527611225.ch9

Editor Information

  1. 4

    Department of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Universitätsstrasse 150, 44780 Bochum, Germany

  2. 5

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

  3. 6

    School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA

Author Information

  1. 1

    Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics (CEGBA), University of Bari, Via Amendola 165/A, 70126 Bari, Italy

  2. 2

    Department of Human Anatomy and Histology, University of Bari, Via Amendola 165/A, 70126 Bari, Italy

  3. 3

    Department of General and Environmental Physiology, University of Bari, Via Amendola 165/A, 70126 Bari, Italy

  4. 5

    Department of Neuroscience, Albert Einstein College of Medicine, 1410 Pelham Parkway S, Bronx, NY 10464, USA

Publication History

  1. Published Online: 31 MAY 2007
  2. Published Print: 20 FEB 2006

ISBN Information

Print ISBN: 9783527310883

Online ISBN: 9783527611225

SEARCH

Keywords:

  • cells of blood-brain interface;
  • responsive astrocytic endfeet;
  • BBB maintenance;
  • BBB development;
  • BBB damage;
  • role of aquaporins (AQP);
  • brain edema;
  • AQP expression

Summary

This chapter contains sections titled:

  • Introduction

  • Astrocyte Endfeet and BBB Maintenance

  • Astrocyte Endfeet and BBB Development

  • Astrocyte Endfeet and BBB Damage

  • The Role of Aquaporins in BBB Maintenance and Brain Edema

    • AQP Expression and Functional Roles

    • The Role of AQP4 in Brain Edema

      • DMD Animal Models

      • The α-Syntrophin Null Mice

      • The Effect of Lipopolysaccharide on AQP4 Expression

      • AQP4 in Astrocytomas

  • AQP4 Expression in Astrocyte-Endothelial Cocultures

  • References