Chapter 2. The OECD and International Regulatory Acceptance of the Three Rs

  1. Dr. Christoph A Reinhardt
  1. Hugo M. Van Looy and
  2. Herman B. W. M. Koëter

Published Online: 8 OCT 2008

DOI: 10.1002/9783527616053.ch2

Alternatives to Animal Testing: New Ways in the Biomedical Sciences, Trends and Progress, Second Edition

Alternatives to Animal Testing: New Ways in the Biomedical Sciences, Trends and Progress, Second Edition

How to Cite

Van Looy, H. M. and Koëter, H. B. W. M. (1994) The OECD and International Regulatory Acceptance of the Three Rs, in Alternatives to Animal Testing: New Ways in the Biomedical Sciences, Trends and Progress, Second Edition (ed C. A. Reinhardt), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527616053.ch2

Editor Information

  1. SIAT Swiss Institute for Alternatives to Animal Testing, Technopark, Pfingstweidstr. 30, CH-8005 Zürich

Publication History

  1. Published Online: 8 OCT 2008
  2. Published Print: 24 FEB 1994

ISBN Information

Print ISBN: 9783527300433

Online ISBN: 9783527616053

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Keywords:

  • developed and adopted;
  • generating data;
  • phototoxicity;
  • magnitude;
  • effective screening

Summary

The work of the Organisation for Economic Cooperation and Development (OECD) has been pivotal in reaching a consensus on methods of testing that can be used to fulfill national regulatory requirements and, at the same time, to develop data that are acceptable in other countries. Within the program of the OECD, utmost attention is given to incorporating Three Rs improvements, whenever possible and practicable. Today, and for the purpose of regulatory testing, it seems that in vitro alternatives have the limited role of screening chemicals, i.e. identifying those for which full in vivo testing would be a useless and wasteful exercise. It is recognized that the scientific validation of promising in vitro methods is the safest route towards regulatory acceptance. But it is also recognized that this route is extremely resource intensive. An alternative route, that of confidence building, is suggested in this paper.