Chapter 7. The RIVM Center for Alternatives to Animal Testing and the Concept of the Three Rs in the Quality Control of Vaccines

  1. Dr. Christoph A Reinhardt
  1. Coenraad F. M. Hendriksen

Published Online: 8 OCT 2008

DOI: 10.1002/9783527616053.ch7

Alternatives to Animal Testing: New Ways in the Biomedical Sciences, Trends and Progress, Second Edition

Alternatives to Animal Testing: New Ways in the Biomedical Sciences, Trends and Progress, Second Edition

How to Cite

Hendriksen, C. F. M. (1994) The RIVM Center for Alternatives to Animal Testing and the Concept of the Three Rs in the Quality Control of Vaccines, in Alternatives to Animal Testing: New Ways in the Biomedical Sciences, Trends and Progress, Second Edition (ed C. A. Reinhardt), Wiley-VCH Verlag GmbH, Weinheim, Germany. doi: 10.1002/9783527616053.ch7

Editor Information

  1. SIAT Swiss Institute for Alternatives to Animal Testing, Technopark, Pfingstweidstr. 30, CH-8005 Zürich

Publication History

  1. Published Online: 8 OCT 2008
  2. Published Print: 24 FEB 1994

ISBN Information

Print ISBN: 9783527300433

Online ISBN: 9783527616053

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Keywords:

  • alternatives to animal testing;
  • vitro method;
  • creation and awarding;
  • quantitative bioassays;
  • pharmacopoeia

Summary

Each strategy for reducing and refining the use of animals will be successful only if it includes activities that involve institute management and the individual scientist. At these levels in particular, people have the responsibility for the planning and organization of animal experiments, and their interest in alternatives is of utmost importance. A very effective and direct way to make these groups sensitive to the concept of the Three Rs is the establishment of institute-linked centers for alternatives to animal methods. This paper describes the goals and activities of such a center at the National Institute of Public Health and Environmental Protection (RIVM) in the Netherlands. The RIVM is active in various fields of biomedical research, such as toxicology and pharmacology, and in the production and quality control of vaccines. Especially in the last-mentioned field, large numbers of animals are used. Detailed information is given on RIVM activities with respect to the development and validation of alternative methods in potency testing of bacterial vaccines.