Chapter 5. Biology of Adherent Cells in Microgravity

  1. Dr.rer.nat. Enno Brinckmann Senior Biologist2,3
  1. Charles A. Lambert,
  2. Charles M. Lapière and
  3. Betty V. Nusgens

Published Online: 18 OCT 2007

DOI: 10.1002/9783527617005.ch5

Biology in Space and Life on Earth: Effects of Spaceflight on Biological Systems

Biology in Space and Life on Earth: Effects of Spaceflight on Biological Systems

How to Cite

Lambert, C. A., Lapière, C. M. and Nusgens, B. V. (2007) Biology of Adherent Cells in Microgravity, in Biology in Space and Life on Earth: Effects of Spaceflight on Biological Systems (ed E. Brinckmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527617005.ch5

Editor Information

  1. 2

    ESA/HME-GPL, ESTEC, Postbus 299, 2200 AG Noordwijk, The Netherlands

  2. 3

    ESA (retired), Eschenweg 16, 26789 Leer, Germany

Author Information

  1. Laboratory of Connective Tissues Biology, University of Liège, Tour de Pathologie, B23/3, 4000 Liège, Belgium

Publication History

  1. Published Online: 18 OCT 2007
  2. Published Print: 22 AUG 2007

ISBN Information

Print ISBN: 9783527406685

Online ISBN: 9783527617005

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Keywords:

  • biology;
  • space;
  • life on earth;
  • adherent cells;
  • microgravity;
  • medical disturbances in astronauts;
  • mechano-receptivity;
  • mechano-reactivity

Summary

This chapter contains sections titled:

  • Why Cell Biology Research in Microgravity?

  • Medical Disturbances in Astronauts

    • Similarity to Diseases on Earth

    • Cell Types Potentially Involved

  • Mechano-receptivity and -reactivity of Adherent Cells in Culture

    • Mechano-transduction at the Cell–Matrix Contacts

    • Mechano-transduction at the Cell–Cell Contacts

    • The Cytoskeleton Network and its Control by the Small RhoGTPases

    • Cells React to Mechanical Stress and Relaxation

  • Microgravity, the Loss of a Force, Leading to Cellular Disturbances

    • Biological View of the Biophysical Concepts

    • Short Time Microgravity and Space Flights

    • Modelled Altered Gravity

      • Averaging the g-Vector

      • Free-fall Simulation

      • Diamagnetic Levitation

      • Hypergravity

  • From Ground Research to Investigations in Microgravity

    • Testable Hypotheses

    • Experimental Strategy and Constraints

    • The Future