Chapter 6. Microgravity and Bone Cell Mechanosensitivity

  1. Dr.rer.nat. Enno Brinckmann Senior Biologist3,4
  1. Rommel G. Bacabac1,
  2. Jack J. W. A. Van Loon2 and
  3. Jenneke Klein-Nulend1

Published Online: 18 OCT 2007

DOI: 10.1002/9783527617005.ch6

Biology in Space and Life on Earth: Effects of Spaceflight on Biological Systems

Biology in Space and Life on Earth: Effects of Spaceflight on Biological Systems

How to Cite

Bacabac, R. G., Van Loon, J. J. W. A. and Klein-Nulend, J. (2007) Microgravity and Bone Cell Mechanosensitivity, in Biology in Space and Life on Earth: Effects of Spaceflight on Biological Systems (ed E. Brinckmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527617005.ch6

Editor Information

  1. 3

    ESA/HME-GPL, ESTEC, Postbus 299, 2200 AG Noordwijk, The Netherlands

  2. 4

    ESA (retired), Eschenweg 16, 26789 Leer, Germany

Author Information

  1. 1

    ACTA-Vrije Universiteit, Department Oral Cell Biology, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands

  2. 2

    DESC (Dutch Experiment Support Center), ACTA-Free University, Department Oral Biology, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands

Publication History

  1. Published Online: 18 OCT 2007
  2. Published Print: 22 AUG 2007

ISBN Information

Print ISBN: 9783527406685

Online ISBN: 9783527617005

SEARCH

Keywords:

  • biology;
  • space;
  • life on earth;
  • microgravity;
  • bone cell mechanosensitivity;
  • signal transduction in mechanosensing;
  • rate-dependent response;
  • single cell response to mechanical loading;
  • extreme condition

Summary

This chapter contains sections titled:

  • Overview

  • Introduction

  • Mechanotransduction in Bone

  • Signal Transduction in Mechanosensing

  • Single Cell Response to Mechanical Loading

  • Rate-dependent Response by Bone Cells

  • Implications of Threshold Activation: Enhanced Response to Stochastic Stress

  • Stress Response and Cellular Deformation

  • Towards a Quantitative Description of Bone Cell Mechanosensitivity

  • Implications for the Extreme Condition of Unloading Microgravity