Chapter 7. Bone Cell Biology in Microgravity

  1. Dr.rer.nat. Enno Brinckmann Senior Biologist3,4
  1. Geert Carmeliet1,
  2. Lieve Coenegrachts1 and
  3. Roger Bouillon2

Published Online: 18 OCT 2007

DOI: 10.1002/9783527617005.ch7

Biology in Space and Life on Earth: Effects of Spaceflight on Biological Systems

Biology in Space and Life on Earth: Effects of Spaceflight on Biological Systems

How to Cite

Carmeliet, G., Coenegrachts, L. and Bouillon, R. (2007) Bone Cell Biology in Microgravity, in Biology in Space and Life on Earth: Effects of Spaceflight on Biological Systems (ed E. Brinckmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527617005.ch7

Editor Information

  1. 3

    ESA/HME-GPL, ESTEC, Postbus 299, 2200 AG Noordwijk, The Netherlands

  2. 4

    ESA (retired), Eschenweg 16, 26789 Leer, Germany

Author Information

  1. 1

    Laboratory of Experimental Medicine & Endocrinology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium

  2. 2

    Laboratory for Experimental Medicine and Endocrinology, K.Universiteit Leuven, Gasthuisberg, O&N, Herestraat 49, 3000 Leuven, Belgium

Publication History

  1. Published Online: 18 OCT 2007
  2. Published Print: 22 AUG 2007

ISBN Information

Print ISBN: 9783527406685

Online ISBN: 9783527617005

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Keywords:

  • biology;
  • space;
  • life on earth;
  • bone cell biology;
  • microgravity;
  • bone remodelling;
  • human studies;
  • space flight;
  • decreased bone formation;
  • altered osteoblastic behaviour

Summary

This chapter contains sections titled:

  • Overview

  • Introduction

  • Bone Remodelling: An Equilibrium between Osteoblasts and Osteoclasts

  • Human Studies: Response of Bone to Space Flight

  • Space Flight and Unloading in the Rat Mimics Human Bone Loss

  • Mechanisms of Decreased Bone Formation Induced by Unloading or Space Flight

  • Are Osteoblastic Cells In Vitro Responding to Altered Gravity Conditions?

    • Proliferation and Apoptosis

    • Differentiation: Matrix Production

    • Differentiation: Growth Factors

  • Potential Mechanisms of Altered Osteoblastic Behaviour

  • Conclusion