Chapter 9. Evaluation of Environmental Radiation Effects at the Single Cell Level in Space and on Earth

  1. Dr.rer.nat. Enno Brinckmann Senior Biologist3,4
  1. Patrick Van Oostveldt1,
  2. Geert Meesen1,
  3. Philippe Baert1 and
  4. André Poffijn2

Published Online: 18 OCT 2007

DOI: 10.1002/9783527617005.ch9

Biology in Space and Life on Earth: Effects of Spaceflight on Biological Systems

Biology in Space and Life on Earth: Effects of Spaceflight on Biological Systems

How to Cite

Van Oostveldt, P., Meesen, G., Baert, P. and Poffijn, A. (2007) Evaluation of Environmental Radiation Effects at the Single Cell Level in Space and on Earth, in Biology in Space and Life on Earth: Effects of Spaceflight on Biological Systems (ed E. Brinckmann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527617005.ch9

Editor Information

  1. 3

    ESA/HME-GPL, ESTEC, Postbus 299, 2200 AG Noordwijk, The Netherlands

  2. 4

    ESA (retired), Eschenweg 16, 26789 Leer, Germany

Author Information

  1. 1

    University of Ghent, Department Molecular Biotechnology, Coupure Links 653, 9000 Gent, Belgium

  2. 2

    University of Ghent, Department Subatomic and Radiation Physics, Proeftuinstraat, 9000 Gent, Belgium

Publication History

  1. Published Online: 18 OCT 2007
  2. Published Print: 22 AUG 2007

ISBN Information

Print ISBN: 9783527406685

Online ISBN: 9783527617005

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Keywords:

  • biology;
  • environmental radiation effects;
  • single cell level;
  • space;
  • earth;
  • HZE track detection;
  • RAMIROS experiment;
  • combination radiation with biological stress;
  • radiation and gravity

Summary

This chapter contains sections titled:

  • Introduction

  • The Space Radiation Environment

  • HZE Track Detection

    • Confocal Scanning Laser Microscopy for Track Analysis in PADC

    • Time-resolved Track Detection

  • Results of the RAMIROS Experiment on board of the Soyuz Taxi Flight to the ISS

    • Methods

    • Results and Discussion

      • Retrieval of Cell Cultures

      • Number of HZE Tracks

      • Correlation between HZE Hit and DNA Damage at Single Cell Level

      • Space versus Ground Samples

      • HZE Hits Before and After Fixation

      • Conclusions

  • Combination of Radiation with other Biological Stress in Space Travel

  • Interactions between Radiation and Gravity

  • General Conclusions and Perspectives